Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01002-w |
| _version_ | 1797863386850000896 |
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| author | Ruifang Sun Yang Yang Weidong Lü Yanqi Yang Yulong Li Zhigang Liu Dongmei Diao Yang Wang Su’e Chang Mengnan Lu Qiuyu Jiang Bingling Dai Xiaobin Ma Chang’an Zhao Moqi Lü Juan Zhang Caixia Ding Na Li Jian Zhang Zhengtao Xiao Dangxia Zhou Chen Huang |
| author_facet | Ruifang Sun Yang Yang Weidong Lü Yanqi Yang Yulong Li Zhigang Liu Dongmei Diao Yang Wang Su’e Chang Mengnan Lu Qiuyu Jiang Bingling Dai Xiaobin Ma Chang’an Zhao Moqi Lü Juan Zhang Caixia Ding Na Li Jian Zhang Zhengtao Xiao Dangxia Zhou Chen Huang |
| author_sort | Ruifang Sun |
| collection | DOAJ |
| description | Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in colon carcinoma We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified. |
| first_indexed | 2024-04-09T22:35:50Z |
| format | Article |
| id | doaj.art-3946e8f637bf442681ce84bdbfde0934 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-09T22:35:50Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-3946e8f637bf442681ce84bdbfde09342023-03-22T12:29:39ZengBMCCell & Bioscience2045-37012023-03-0113111510.1186/s13578-023-01002-wSingle-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progressionRuifang Sun0Yang Yang1Weidong Lü2Yanqi Yang3Yulong Li4Zhigang Liu5Dongmei Diao6Yang Wang7Su’e Chang8Mengnan Lu9Qiuyu Jiang10Bingling Dai11Xiaobin Ma12Chang’an Zhao13Moqi Lü14Juan Zhang15Caixia Ding16Na Li17Jian Zhang18Zhengtao Xiao19Dangxia Zhou20Chen Huang21Department of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversitySchool of Public Health, Shaanxi University of Chinese MedicineDepartment of Thoracic Surgery, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong UniversityDepartment of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Gastroenterology, Shaanxi Provincial People’s HospitalDepartment of Thoracic Surgery, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong UniversityDepartment of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversitySchool of Pharmacy, Health Science Center, Xi’an Jiaotong UniversityDepartment of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Pathology, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong UniversityDepartment of Pathology, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong UniversitySchool of Pharmacy, Xinxiang Medical UniversityDepartment of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong UniversityHighlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in colon carcinoma We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified.https://doi.org/10.1186/s13578-023-01002-wSingle cellColon adenomaColon cancerCancer development |
| spellingShingle | Ruifang Sun Yang Yang Weidong Lü Yanqi Yang Yulong Li Zhigang Liu Dongmei Diao Yang Wang Su’e Chang Mengnan Lu Qiuyu Jiang Bingling Dai Xiaobin Ma Chang’an Zhao Moqi Lü Juan Zhang Caixia Ding Na Li Jian Zhang Zhengtao Xiao Dangxia Zhou Chen Huang Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression Cell & Bioscience Single cell Colon adenoma Colon cancer Cancer development |
| title | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| title_full | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| title_fullStr | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| title_full_unstemmed | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| title_short | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| title_sort | single cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
| topic | Single cell Colon adenoma Colon cancer Cancer development |
| url | https://doi.org/10.1186/s13578-023-01002-w |
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