Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset...

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Bibliographic Details
Main Authors: Ruifang Sun, Yang Yang, Weidong Lü, Yanqi Yang, Yulong Li, Zhigang Liu, Dongmei Diao, Yang Wang, Su’e Chang, Mengnan Lu, Qiuyu Jiang, Bingling Dai, Xiaobin Ma, Chang’an Zhao, Moqi Lü, Juan Zhang, Caixia Ding, Na Li, Jian Zhang, Zhengtao Xiao, Dangxia Zhou, Chen Huang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Single cell
Colon adenoma
Colon cancer
Cancer development
Online Access:https://doi.org/10.1186/s13578-023-01002-w

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