Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory
Converging evidence from both human and animal studies has highlighted the pervasive role of the neuropeptide arginine vasopressin (AVP), which is mediated by arginine vasopressin receptor 1A (AVPR1A), in both social and nonsocial learning and memory. However, the effect of genetic variants in AVPR1...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920307692 |
| _version_ | 1818857588979138560 |
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| author | Yan Zhang Dan Zhu Peng Zhang Wei Li Wen Qin Feng Liu Jiayuan Xu Qiang Xu Junping Wang Zhaoxiang Ye Chunshui Yu |
| author_facet | Yan Zhang Dan Zhu Peng Zhang Wei Li Wen Qin Feng Liu Jiayuan Xu Qiang Xu Junping Wang Zhaoxiang Ye Chunshui Yu |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Converging evidence from both human and animal studies has highlighted the pervasive role of the neuropeptide arginine vasopressin (AVP), which is mediated by arginine vasopressin receptor 1A (AVPR1A), in both social and nonsocial learning and memory. However, the effect of genetic variants in AVPR1A on verbal learning and memory is unknown. The hippocampus is a heterogeneous structure that consists of several anatomically and functionally distinct subfields, and it is the principal target structure for the memory-enhancing effect of AVP. We tested the hypothesis that genetic variants in the RS3 and RS1 repeat polymorphisms may influence verbal learning and memory performance evaluated by the California Verbal Learning Test-II (CVLT-II) by modulating the gray matter volume (GMV) and resting-state functional connectivity (rsFC) of whole hippocampus and its subfields in a large cohort of young healthy subjects (n = 1001). Using a short/long classification scheme for the repeat length of RS3 and RS1, we found that the individuals carrying more short alleles of RS3-RS1 haplotypes had poorer learning and memory performance compared to that of those carrying more long alleles. We also revealed that individuals carrying more short alleles exhibited a significantly smaller GMV in the left cornu ammonis (CA)2/3 and weaker rsFC of the left CA2/3-bilateral thalamic (primarily in medial prefrontal subfields) compared to those carrying more long alleles. Furthermore, multiple mediation analysis confirmed that these two hippocampal imaging measures jointly and fully mediated the relationship between the genetic variants in AVPR1A RS3-RS1 haplotypes and the individual differences in verbal learning and memory performance. Our results suggest that genetic variants in AVPR1A RS3-RS1 haplotypes may affect verbal learning and memory performance in part by modulating the left hippocampal CA2/3 structure and its rsFC with the thalamus. |
| first_indexed | 2024-12-19T08:42:47Z |
| format | Article |
| id | doaj.art-39475e061381485282d37dc3e2170a12 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-19T08:42:47Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-39475e061381485282d37dc3e2170a122022-12-21T20:28:53ZengElsevierNeuroImage1095-95722020-11-01222117283Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memoryYan Zhang0Dan Zhu1Peng Zhang2Wei Li3Wen Qin4Feng Liu5Jiayuan Xu6Qiang Xu7Junping Wang8Zhaoxiang Ye9Chunshui Yu10Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, ChinaDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, ChinaDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China; Corresponding author.Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, China; Corresponding author.Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Corresponding author.Converging evidence from both human and animal studies has highlighted the pervasive role of the neuropeptide arginine vasopressin (AVP), which is mediated by arginine vasopressin receptor 1A (AVPR1A), in both social and nonsocial learning and memory. However, the effect of genetic variants in AVPR1A on verbal learning and memory is unknown. The hippocampus is a heterogeneous structure that consists of several anatomically and functionally distinct subfields, and it is the principal target structure for the memory-enhancing effect of AVP. We tested the hypothesis that genetic variants in the RS3 and RS1 repeat polymorphisms may influence verbal learning and memory performance evaluated by the California Verbal Learning Test-II (CVLT-II) by modulating the gray matter volume (GMV) and resting-state functional connectivity (rsFC) of whole hippocampus and its subfields in a large cohort of young healthy subjects (n = 1001). Using a short/long classification scheme for the repeat length of RS3 and RS1, we found that the individuals carrying more short alleles of RS3-RS1 haplotypes had poorer learning and memory performance compared to that of those carrying more long alleles. We also revealed that individuals carrying more short alleles exhibited a significantly smaller GMV in the left cornu ammonis (CA)2/3 and weaker rsFC of the left CA2/3-bilateral thalamic (primarily in medial prefrontal subfields) compared to those carrying more long alleles. Furthermore, multiple mediation analysis confirmed that these two hippocampal imaging measures jointly and fully mediated the relationship between the genetic variants in AVPR1A RS3-RS1 haplotypes and the individual differences in verbal learning and memory performance. Our results suggest that genetic variants in AVPR1A RS3-RS1 haplotypes may affect verbal learning and memory performance in part by modulating the left hippocampal CA2/3 structure and its rsFC with the thalamus.http://www.sciencedirect.com/science/article/pii/S1053811920307692Verbal memoryHippocampal subfieldsCalifornia Verbal Learning TestFreeSurferGray matter volumeFunctional connectivity |
| spellingShingle | Yan Zhang Dan Zhu Peng Zhang Wei Li Wen Qin Feng Liu Jiayuan Xu Qiang Xu Junping Wang Zhaoxiang Ye Chunshui Yu Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory NeuroImage Verbal memory Hippocampal subfields California Verbal Learning Test FreeSurfer Gray matter volume Functional connectivity |
| title | Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory |
| title_full | Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory |
| title_fullStr | Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory |
| title_full_unstemmed | Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory |
| title_short | Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory |
| title_sort | neural mechanisms of avpr1a rs3 rs1 haplotypes that impact verbal learning and memory |
| topic | Verbal memory Hippocampal subfields California Verbal Learning Test FreeSurfer Gray matter volume Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920307692 |
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