Regenerative medicine in Fuchs' endothelial corneal dystrophy
The management of Fuchs' endothelial corneal dystrophy (FECD) has evolved rapidly since the introduction of endothelial keratoplasty (EK). In recent years, advances in our understanding of endothelial cell biology, in particular with respect to the regenerative capacity of endothelial cells, ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Taiwan Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2021;volume=11;issue=2;spage=122;epage=131;aulast=Yuan |
| _version_ | 1819126885235294208 |
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| author | Amy E Yuan Roberto Pineda |
| author_facet | Amy E Yuan Roberto Pineda |
| author_sort | Amy E Yuan |
| collection | DOAJ |
| description | The management of Fuchs' endothelial corneal dystrophy (FECD) has evolved rapidly since the introduction of endothelial keratoplasty (EK). In recent years, advances in our understanding of endothelial cell biology, in particular with respect to the regenerative capacity of endothelial cells, have opened the door to novel therapeutic options that stray from the traditional paradigm of allograft transplantation. We review the development of descemetorhexis without EK (DWEK) as a primary treatment for FECD and discuss the lessons learned to date about the mechanism of wound healing, surgical technique, patient selection, and refractive outcomes. Multiple randomized clinical trials are currently underway to evaluate the potential for pharmacological supplementation with rho-associated kinase inhibitors to increase the success rate of corneal clearance following DWEK. Biologic supplementation with intracameral endothelial cell injection and acellular Descemet's membrane transplantation are other avenues of adjuvant therapy. DWEK is a promising surgical option for management of a subset of FECD patients. |
| first_indexed | 2024-12-22T08:03:08Z |
| format | Article |
| id | doaj.art-3948a21c08314068bb6b64787370d458 |
| institution | Directory Open Access Journal |
| issn | 2211-5056 2211-5072 |
| language | English |
| last_indexed | 2024-12-22T08:03:08Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj.art-3948a21c08314068bb6b64787370d4582022-12-21T18:33:12ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722021-01-0111212213110.4103/tjo.tjo_23_20Regenerative medicine in Fuchs' endothelial corneal dystrophyAmy E YuanRoberto PinedaThe management of Fuchs' endothelial corneal dystrophy (FECD) has evolved rapidly since the introduction of endothelial keratoplasty (EK). In recent years, advances in our understanding of endothelial cell biology, in particular with respect to the regenerative capacity of endothelial cells, have opened the door to novel therapeutic options that stray from the traditional paradigm of allograft transplantation. We review the development of descemetorhexis without EK (DWEK) as a primary treatment for FECD and discuss the lessons learned to date about the mechanism of wound healing, surgical technique, patient selection, and refractive outcomes. Multiple randomized clinical trials are currently underway to evaluate the potential for pharmacological supplementation with rho-associated kinase inhibitors to increase the success rate of corneal clearance following DWEK. Biologic supplementation with intracameral endothelial cell injection and acellular Descemet's membrane transplantation are other avenues of adjuvant therapy. DWEK is a promising surgical option for management of a subset of FECD patients.http://www.e-tjo.org/article.asp?issn=2211-5056;year=2021;volume=11;issue=2;spage=122;epage=131;aulast=Yuandescemet's stripping onlydescemetorhexis without endothelial keratoplastyfuchs' endothelial corneal dystrophyregenerative medicinerho-associated kinase inhibitor |
| spellingShingle | Amy E Yuan Roberto Pineda Regenerative medicine in Fuchs' endothelial corneal dystrophy Taiwan Journal of Ophthalmology descemet's stripping only descemetorhexis without endothelial keratoplasty fuchs' endothelial corneal dystrophy regenerative medicine rho-associated kinase inhibitor |
| title | Regenerative medicine in Fuchs' endothelial corneal dystrophy |
| title_full | Regenerative medicine in Fuchs' endothelial corneal dystrophy |
| title_fullStr | Regenerative medicine in Fuchs' endothelial corneal dystrophy |
| title_full_unstemmed | Regenerative medicine in Fuchs' endothelial corneal dystrophy |
| title_short | Regenerative medicine in Fuchs' endothelial corneal dystrophy |
| title_sort | regenerative medicine in fuchs endothelial corneal dystrophy |
| topic | descemet's stripping only descemetorhexis without endothelial keratoplasty fuchs' endothelial corneal dystrophy regenerative medicine rho-associated kinase inhibitor |
| url | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2021;volume=11;issue=2;spage=122;epage=131;aulast=Yuan |
| work_keys_str_mv | AT amyeyuan regenerativemedicineinfuchsendothelialcornealdystrophy AT robertopineda regenerativemedicineinfuchsendothelialcornealdystrophy |