Effect of onions tunic extract on sodium oxalate-induced acute kidney injury
Abstract Acute kidney injury (AKI) is one of the global health concerns afflicting the human population and urolithiasis (kidney stone), especially the calcium oxalate stone is the most prominent amongst the stone formers with a huge recurrence rate. This study elucidates the ameliorative potential...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-02-01
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| Series: | Clinical Phytoscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40816-024-00366-x |
| _version_ | 1797272745746104320 |
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| author | Olanrewaju Sam Olayeriju Damilola Alex Omoboyowa |
| author_facet | Olanrewaju Sam Olayeriju Damilola Alex Omoboyowa |
| author_sort | Olanrewaju Sam Olayeriju |
| collection | DOAJ |
| description | Abstract Acute kidney injury (AKI) is one of the global health concerns afflicting the human population and urolithiasis (kidney stone), especially the calcium oxalate stone is the most prominent amongst the stone formers with a huge recurrence rate. This study elucidates the ameliorative potential of the tunic of onions against Wistar kidney rats toxified with sodium oxalate. Ethylacetate extract of the tunic of onions otherwise regarded as Onions peel extract (OPE) in this study was prepared to get the flavonol-rich extracts. Adult male Wistar rats received 70 mg/kg body weight sodium oxalate with or without co-treatment with OPE, quercetin or cystone. Biochemical analyses were carried out on the plasma and urine, followed by a histopathological assessment of the kidney. Intoxication with sodium oxalate brought about electrolyte imbalance, nephrotic syndrome (high concentrations of total protein and albumin in the urine and low concentrations in the plasma) reduced renal function (low renal clearance of creatinine and urea) and damage to the kidney as well as fluid accumulation. Treatment with flavonol extract from onion tunic mitigated these deleterious changes as a result of sodium oxalate intoxication. The finding suggests that onion peel has the potential to prevent damage arising from oxalate toxicity in the kidney. Graphical Abstract |
| first_indexed | 2024-03-07T14:33:46Z |
| format | Article |
| id | doaj.art-3948f5fccfa349b393b58b356143087e |
| institution | Directory Open Access Journal |
| issn | 2199-1197 |
| language | English |
| last_indexed | 2024-03-07T14:33:46Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Clinical Phytoscience |
| spelling | doaj.art-3948f5fccfa349b393b58b356143087e2024-03-05T20:44:21ZengSpringerOpenClinical Phytoscience2199-11972024-02-0110111110.1186/s40816-024-00366-xEffect of onions tunic extract on sodium oxalate-induced acute kidney injuryOlanrewaju Sam Olayeriju0Damilola Alex Omoboyowa1Department of Chemical Sciences (Biochemistry Unit), Olusegun Agagu University of Science and TechnologyDepartment of Biochemistry, Adekunle AjasinUniversityAbstract Acute kidney injury (AKI) is one of the global health concerns afflicting the human population and urolithiasis (kidney stone), especially the calcium oxalate stone is the most prominent amongst the stone formers with a huge recurrence rate. This study elucidates the ameliorative potential of the tunic of onions against Wistar kidney rats toxified with sodium oxalate. Ethylacetate extract of the tunic of onions otherwise regarded as Onions peel extract (OPE) in this study was prepared to get the flavonol-rich extracts. Adult male Wistar rats received 70 mg/kg body weight sodium oxalate with or without co-treatment with OPE, quercetin or cystone. Biochemical analyses were carried out on the plasma and urine, followed by a histopathological assessment of the kidney. Intoxication with sodium oxalate brought about electrolyte imbalance, nephrotic syndrome (high concentrations of total protein and albumin in the urine and low concentrations in the plasma) reduced renal function (low renal clearance of creatinine and urea) and damage to the kidney as well as fluid accumulation. Treatment with flavonol extract from onion tunic mitigated these deleterious changes as a result of sodium oxalate intoxication. The finding suggests that onion peel has the potential to prevent damage arising from oxalate toxicity in the kidney. Graphical Abstracthttps://doi.org/10.1186/s40816-024-00366-xAcute kidney injuryKidney stoneOnion tunicNephrotic syndromeToxified |
| spellingShingle | Olanrewaju Sam Olayeriju Damilola Alex Omoboyowa Effect of onions tunic extract on sodium oxalate-induced acute kidney injury Clinical Phytoscience Acute kidney injury Kidney stone Onion tunic Nephrotic syndrome Toxified |
| title | Effect of onions tunic extract on sodium oxalate-induced acute kidney injury |
| title_full | Effect of onions tunic extract on sodium oxalate-induced acute kidney injury |
| title_fullStr | Effect of onions tunic extract on sodium oxalate-induced acute kidney injury |
| title_full_unstemmed | Effect of onions tunic extract on sodium oxalate-induced acute kidney injury |
| title_short | Effect of onions tunic extract on sodium oxalate-induced acute kidney injury |
| title_sort | effect of onions tunic extract on sodium oxalate induced acute kidney injury |
| topic | Acute kidney injury Kidney stone Onion tunic Nephrotic syndrome Toxified |
| url | https://doi.org/10.1186/s40816-024-00366-x |
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