CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation
The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946871/full |
| _version_ | 1817980340003667968 |
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| author | Shi Qian Shi Qian Shi Qian Chunbin Xiong Chunbin Xiong Meiting Wang Meiting Wang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Qinghai Hu Qinghai Hu Haibo Ding Haibo Ding Xiaoxu Han Xiaoxu Han Xiaoxu Han Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang |
| author_facet | Shi Qian Shi Qian Shi Qian Chunbin Xiong Chunbin Xiong Meiting Wang Meiting Wang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Qinghai Hu Qinghai Hu Haibo Ding Haibo Ding Xiaoxu Han Xiaoxu Han Xiaoxu Han Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang |
| author_sort | Shi Qian |
| collection | DOAJ |
| description | The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 expressed NK cells in HIV disease require elucidation. Our study showed that the proportions of CD38+CD39+ NK cells in HIV-infected individuals were positively associated with HIV viral loads and negatively associated with the CD4+ T cell count. Furthermore, CD38+CD39+ NK cells expressed additional inhibitory receptors, TIM-3 and LAG-3, and produced more TGF-β. Moreover, autologous NK cells suppressed the proliferation of CD8+ T and CD4+ T cells of HIV-infected individuals, and inhibiting CD38 and CD39 on NK cells restored CD8+ T and CD4+ T cell proliferation in vitro. In conclusion, these data support a critical role for CD38 and CD39 on NK cells in HIV infection and targeting CD38 and CD39 on NK cells may be a potential therapeutic strategy against HIV infection. |
| first_indexed | 2024-04-13T22:52:51Z |
| format | Article |
| id | doaj.art-39494e475a8447e68144acb8afffb3eb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T22:52:51Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-39494e475a8447e68144acb8afffb3eb2022-12-22T02:26:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.946871946871CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferationShi Qian0Shi Qian1Shi Qian2Chunbin Xiong3Chunbin Xiong4Meiting Wang5Meiting Wang6Zining Zhang7Zining Zhang8Yajing Fu9Yajing Fu10Qinghai Hu11Qinghai Hu12Haibo Ding13Haibo Ding14Xiaoxu Han15Xiaoxu Han16Xiaoxu Han17Hong Shang18Hong Shang19Yongjun Jiang20Yongjun Jiang21National Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaDepartment of Clinical Laboratory, Tianjin Medical University General Hospital, Tianjin, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaUnits of Medical Laboratory, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaNational Health Commission (NHC) Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaThe ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 expressed NK cells in HIV disease require elucidation. Our study showed that the proportions of CD38+CD39+ NK cells in HIV-infected individuals were positively associated with HIV viral loads and negatively associated with the CD4+ T cell count. Furthermore, CD38+CD39+ NK cells expressed additional inhibitory receptors, TIM-3 and LAG-3, and produced more TGF-β. Moreover, autologous NK cells suppressed the proliferation of CD8+ T and CD4+ T cells of HIV-infected individuals, and inhibiting CD38 and CD39 on NK cells restored CD8+ T and CD4+ T cell proliferation in vitro. In conclusion, these data support a critical role for CD38 and CD39 on NK cells in HIV infection and targeting CD38 and CD39 on NK cells may be a potential therapeutic strategy against HIV infection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.946871/fullHIVNK cellsCD38CD39negative regulation |
| spellingShingle | Shi Qian Shi Qian Shi Qian Chunbin Xiong Chunbin Xiong Meiting Wang Meiting Wang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Qinghai Hu Qinghai Hu Haibo Ding Haibo Ding Xiaoxu Han Xiaoxu Han Xiaoxu Han Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation Frontiers in Immunology HIV NK cells CD38 CD39 negative regulation |
| title | CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation |
| title_full | CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation |
| title_fullStr | CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation |
| title_full_unstemmed | CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation |
| title_short | CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation |
| title_sort | cd38 cd39 nk cells associate with hiv disease progression and negatively regulate t cell proliferation |
| topic | HIV NK cells CD38 CD39 negative regulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946871/full |
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