CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 e...

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Bibliographic Details
Main Authors: Shi Qian, Chunbin Xiong, Meiting Wang, Zining Zhang, Yajing Fu, Qinghai Hu, Haibo Ding, Xiaoxu Han, Hong Shang, Yongjun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
HIV
NK cells
CD38
CD39
negative regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.946871/full

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