Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data
Background: Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important. Methods: We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between Mar...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | The Lancet Regional Health. Europe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776220300016 |
| _version_ | 1818609959077675008 |
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| author | Martin P. Grobusch Leisa Weld Abraham Goorhuis Davidson H. Hamer Mirjam Schunk Sabine Jordan Frank P. Mockenhaupt François Chappuis Hilmir Asgeirsson Eric Caumes Mogens Jensenius Perry J.J. van Genderen Francesco Castelli Rogelio López-Velez Vanessa Field Emmanuel Bottieau Israel Molina Christophe Rapp Marta Díaz Ménendez Effrossyni Gkrania-Klotsas Carsten S. Larsen Denis Malvy David Lalloo Federico Gobbi Simin A. Florescu Philippe Gautret Patricia Schlagenhauf |
| author_facet | Martin P. Grobusch Leisa Weld Abraham Goorhuis Davidson H. Hamer Mirjam Schunk Sabine Jordan Frank P. Mockenhaupt François Chappuis Hilmir Asgeirsson Eric Caumes Mogens Jensenius Perry J.J. van Genderen Francesco Castelli Rogelio López-Velez Vanessa Field Emmanuel Bottieau Israel Molina Christophe Rapp Marta Díaz Ménendez Effrossyni Gkrania-Klotsas Carsten S. Larsen Denis Malvy David Lalloo Federico Gobbi Simin A. Florescu Philippe Gautret Patricia Schlagenhauf |
| author_sort | Martin P. Grobusch |
| collection | DOAJ |
| description | Background: Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important. Methods: We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between March 1, 1998 and March 31, 2018. Findings: 103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, and 2,880 (2.8%) during and after travel. Despite increasing numbers of patient encounters over 20 years, the regions of exposure by year of clinic visits have remained stable. In 5-year increments, greater proportions of patients were migrants or visiting friends and relatives (VFR); business travel-associated illness remained stable; tourism-related illness decreased. Falciparum malaria was amongst the most-frequently diagnosed illnesses with 5,254 cases (5.1% of all patients) and the most-frequent cause of death (risk ratio versus all other illnesses 2.5:1). Animal exposures requiring rabies post-exposure prophylaxis increased from 0.7% (1998–2002) to 3.6% (2013–2018). The proportion of patients with seasonal influenza increased from zero in 1998–2002 to 0.9% in 2013–2018. There were 44 cases of viral haemorrhagic fever, most during the past five years. Arboviral infection numbers increased significantly as did the range of presenting arboviral diseases, dengue and chikungunya diagnoses increased by 2.6% and 1%, respectively. Interpretation: Travel medicine must adapt to serve the changing profile of travellers, with an increase in migrants and persons visiting relatives and friends and the strong emergence of vector-borne diseases, with potential for further local transmission in Europe. Funding: This project was supported by a cooperative agreement (U50CK00189) between the Centers for Disease Control and Prevention to the International Society of Travel Medicine (ISTM) and funding from the ISTM and the Public Health Agency of Canada. |
| first_indexed | 2024-12-16T15:06:49Z |
| format | Article |
| id | doaj.art-394b3b70d8f647cdba70c44367add41f |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-12-16T15:06:49Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-394b3b70d8f647cdba70c44367add41f2022-12-21T22:27:05ZengElsevierThe Lancet Regional Health. Europe2666-77622021-02-011100001Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance dataMartin P. Grobusch0Leisa Weld1Abraham Goorhuis2Davidson H. Hamer3Mirjam Schunk4Sabine Jordan5Frank P. Mockenhaupt6François Chappuis7Hilmir Asgeirsson8Eric Caumes9Mogens Jensenius10Perry J.J. van Genderen11Francesco Castelli12Rogelio López-Velez13Vanessa Field14Emmanuel Bottieau15Israel Molina16Christophe Rapp17Marta Díaz Ménendez18Effrossyni Gkrania-Klotsas19Carsten S. Larsen20Denis Malvy21David Lalloo22Federico Gobbi23Simin A. Florescu24Philippe Gautret25Patricia Schlagenhauf26Centre of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centres, location AMC, Amsterdam Infection & Immunity, Amsterdam Public Health, Amsterdam, the Netherlands; Corresponding author.Statistical Consultant, Geneva, SwitzerlandCentre of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centres, location AMC, Amsterdam Infection & Immunity, Amsterdam Public Health, Amsterdam, the NetherlandsDepartment of Global Health, Boston University School of Public Health and Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA, USADepartment of Infectious Diseases and Tropical Medicine (DITM), Ludwig-Maximilians University of Munich, Munich, GermanyDivision of Tropical Medicine, I. Department of Medicine, University Medical Center Hamburg-Eppendorf & Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin & Berlin Institute of Health, Institute of Tropical Medicine and International Health, Berlin, GermanyDivision of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, SwitzerlandDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden & Unit of Infectious Diseases, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, SwedenSorbonne Université, INSERM, Institut Pierre Louis d’Épidémiologie et de Santé Publique (IPLESP), AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies Infectieuses et Tropicales, Paris, FranceDepartment of Infectious Diseases, Oslo University Hospital, Ullevål, Oslo, NorwayDepartment of Microbiology and Infectious Diseases, University Hospital Erasmus MC, Rotterdam, the NetherlandsUniversity of Brescia & ASST Spedali Civili de Brescia, Brescia, ItalyNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital Madrid, Madrid, SpainInterHealth Worldwide, Newington Causeway, London, United KingdomInstitute of Tropical Medicine, Antwerp, BelgiumDepartment of Infectious Diseases, Vall d'Hebron University Hospital, PROSICS Barcelona, Barcelona, SpainInfectious and Tropical Diseases Department, HIA Bégin, Saint-Mandé, FranceNational Referral Unit for Imported Tropical Diseases, Department of Internal Medicine, Hospital Universitario La Paz-Carlos III, IdiPAZ, Madrid, SpainDepartment of Medicine, University of Cambridge, Cambridge, United KingdomDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, DenmarkUnit of Tropical Medicine and Clinical International Health, Department of Infectious and Tropical Diseases, University Hospital Center of Bordeaux & INSERM 1219, University of Bordeaux, Bordeaux, FranceLiverpool School of Tropical Medicine and Tropical Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, United KingdomDepartment of Infectious/Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, ItalyDr. Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, RomaniaUniversity Hospital Institute Méditerranée Infection, Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceUniversity of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers’ Health, Department of Public Health, Institute for Epidemiology, Biostatistics and Prevention, Zürich, SwitzerlandBackground: Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important. Methods: We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between March 1, 1998 and March 31, 2018. Findings: 103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, and 2,880 (2.8%) during and after travel. Despite increasing numbers of patient encounters over 20 years, the regions of exposure by year of clinic visits have remained stable. In 5-year increments, greater proportions of patients were migrants or visiting friends and relatives (VFR); business travel-associated illness remained stable; tourism-related illness decreased. Falciparum malaria was amongst the most-frequently diagnosed illnesses with 5,254 cases (5.1% of all patients) and the most-frequent cause of death (risk ratio versus all other illnesses 2.5:1). Animal exposures requiring rabies post-exposure prophylaxis increased from 0.7% (1998–2002) to 3.6% (2013–2018). The proportion of patients with seasonal influenza increased from zero in 1998–2002 to 0.9% in 2013–2018. There were 44 cases of viral haemorrhagic fever, most during the past five years. Arboviral infection numbers increased significantly as did the range of presenting arboviral diseases, dengue and chikungunya diagnoses increased by 2.6% and 1%, respectively. Interpretation: Travel medicine must adapt to serve the changing profile of travellers, with an increase in migrants and persons visiting relatives and friends and the strong emergence of vector-borne diseases, with potential for further local transmission in Europe. Funding: This project was supported by a cooperative agreement (U50CK00189) between the Centers for Disease Control and Prevention to the International Society of Travel Medicine (ISTM) and funding from the ISTM and the Public Health Agency of Canada.http://www.sciencedirect.com/science/article/pii/S2666776220300016EurotravnetGeosentinelInfectious diseasesSentinel surveillancetravel |
| spellingShingle | Martin P. Grobusch Leisa Weld Abraham Goorhuis Davidson H. Hamer Mirjam Schunk Sabine Jordan Frank P. Mockenhaupt François Chappuis Hilmir Asgeirsson Eric Caumes Mogens Jensenius Perry J.J. van Genderen Francesco Castelli Rogelio López-Velez Vanessa Field Emmanuel Bottieau Israel Molina Christophe Rapp Marta Díaz Ménendez Effrossyni Gkrania-Klotsas Carsten S. Larsen Denis Malvy David Lalloo Federico Gobbi Simin A. Florescu Philippe Gautret Patricia Schlagenhauf Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data The Lancet Regional Health. Europe Eurotravnet Geosentinel Infectious diseases Sentinel surveillance travel |
| title | Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data |
| title_full | Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data |
| title_fullStr | Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data |
| title_full_unstemmed | Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data |
| title_short | Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data |
| title_sort | travel related infections presenting in europe a 20 year analysis of eurotravnet surveillance data |
| topic | Eurotravnet Geosentinel Infectious diseases Sentinel surveillance travel |
| url | http://www.sciencedirect.com/science/article/pii/S2666776220300016 |
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