Recent advances in renal regeneration [version 1; referees: 2 approved]
Regeneration of a functional kidney from pluripotent stem cells (PSCs) is challenging because of its complex structure. Kidneys are derived from embryonic metanephros, which are composed of three progenitor cells: nephron progenitors, ureteric bud, and stromal progenitors. Nephron progenitors and ur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-02-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-216/v1 |
| _version_ | 1818872913146675200 |
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| author | Sho Hasegawa Tetsuhiro Tanaka Masaomi Nangaku |
| author_facet | Sho Hasegawa Tetsuhiro Tanaka Masaomi Nangaku |
| author_sort | Sho Hasegawa |
| collection | DOAJ |
| description | Regeneration of a functional kidney from pluripotent stem cells (PSCs) is challenging because of its complex structure. Kidneys are derived from embryonic metanephros, which are composed of three progenitor cells: nephron progenitors, ureteric bud, and stromal progenitors. Nephron progenitors and ureteric bud have been induced successfully from PSCs as a result of the understanding of their detailed developmental process through cell-lineage tracing analysis. Moreover, these induced progenitors can be used to reconstruct the three-dimensional (3D) structure of kidneys in vitro, including glomeruli with podocytes, renal tubules, and the branching ureters. Induction of the remaining renal progenitors (that is, stromal progenitors from PSCs and the further maturation of reconstructed kidneys) needs to be studied extensively to regenerate functional and sophisticated kidneys from PSCs. In addition to the proper induction of renal progenitors, new bioengineering methods such as decellularization and 3D bioprinting and the recent advancements in the regeneration of kidneys in other species are promising leads for regenerating the complex spatial arrangement of kidneys, including the vascular network and urinary excretion pathway in humans. |
| first_indexed | 2024-12-19T12:46:22Z |
| format | Article |
| id | doaj.art-394b74e0b2af4dbe8b91a1f85d09cc36 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T12:46:22Z |
| publishDate | 2019-02-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-394b74e0b2af4dbe8b91a1f85d09cc362022-12-21T20:20:46ZengF1000 Research LtdF1000Research2046-14022019-02-01810.12688/f1000research.17127.118725Recent advances in renal regeneration [version 1; referees: 2 approved]Sho Hasegawa0Tetsuhiro Tanaka1Masaomi Nangaku2Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, JapanDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, JapanDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, JapanRegeneration of a functional kidney from pluripotent stem cells (PSCs) is challenging because of its complex structure. Kidneys are derived from embryonic metanephros, which are composed of three progenitor cells: nephron progenitors, ureteric bud, and stromal progenitors. Nephron progenitors and ureteric bud have been induced successfully from PSCs as a result of the understanding of their detailed developmental process through cell-lineage tracing analysis. Moreover, these induced progenitors can be used to reconstruct the three-dimensional (3D) structure of kidneys in vitro, including glomeruli with podocytes, renal tubules, and the branching ureters. Induction of the remaining renal progenitors (that is, stromal progenitors from PSCs and the further maturation of reconstructed kidneys) needs to be studied extensively to regenerate functional and sophisticated kidneys from PSCs. In addition to the proper induction of renal progenitors, new bioengineering methods such as decellularization and 3D bioprinting and the recent advancements in the regeneration of kidneys in other species are promising leads for regenerating the complex spatial arrangement of kidneys, including the vascular network and urinary excretion pathway in humans.https://f1000research.com/articles/8-216/v1 |
| spellingShingle | Sho Hasegawa Tetsuhiro Tanaka Masaomi Nangaku Recent advances in renal regeneration [version 1; referees: 2 approved] F1000Research |
| title | Recent advances in renal regeneration [version 1; referees: 2 approved] |
| title_full | Recent advances in renal regeneration [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in renal regeneration [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in renal regeneration [version 1; referees: 2 approved] |
| title_short | Recent advances in renal regeneration [version 1; referees: 2 approved] |
| title_sort | recent advances in renal regeneration version 1 referees 2 approved |
| url | https://f1000research.com/articles/8-216/v1 |
| work_keys_str_mv | AT shohasegawa recentadvancesinrenalregenerationversion1referees2approved AT tetsuhirotanaka recentadvancesinrenalregenerationversion1referees2approved AT masaominangaku recentadvancesinrenalregenerationversion1referees2approved |