Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic
Abstract Background In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims The objective of this cross‐sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid‐based cytology in the...
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4502 |
| _version_ | 1818246148124573696 |
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| author | Phimpha Paboriboune Keokedthong Phongsavan Phetsamone Arounlangsy Bruno Flaissier Oukham Aphayarath Prasit Phimmasone Ketmala Banchongphanith Mixi Xayaovong Gonzague Jourdain Anne‐Marie Schott Mitra Saadatian‐Elahi Laurent Magaud Amna Klich Nicole Ngo‐Giang‐Huong Isabelle Heard Muriel Rabilloud Valentina Sanchez Picot Christophe Longuet |
| author_facet | Phimpha Paboriboune Keokedthong Phongsavan Phetsamone Arounlangsy Bruno Flaissier Oukham Aphayarath Prasit Phimmasone Ketmala Banchongphanith Mixi Xayaovong Gonzague Jourdain Anne‐Marie Schott Mitra Saadatian‐Elahi Laurent Magaud Amna Klich Nicole Ngo‐Giang‐Huong Isabelle Heard Muriel Rabilloud Valentina Sanchez Picot Christophe Longuet |
| author_sort | Phimpha Paboriboune |
| collection | DOAJ |
| description | Abstract Background In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims The objective of this cross‐sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid‐based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV‐1). Materials & Methods Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid‐based cytology, careHPV™ test, and HPV‐16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests. Results Of the 631 women with follow‐up, 331 were human papillomavirus (HPV) negative. High‐grade squamous intraepithelial lesions were found in 37 women, biopsy‐proven high‐grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high‐grade cervical lesion or carcinoma detected after abnormal careHPV™ test was higher (6.02%; 95% confidence interval [CI]: 4.4–8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2–6.5). careHPV™ and HPV‐16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4–89.5) and specificity (92.2%; 95% CI: 89.8–94.2). HPV‐16 was the most frequently detected genotype. Conclusions careHPV™ test represents a screening option in Lao PDR, particularly in women living with HIV‐1 because of higher prevalence of chronic HPV in this population. |
| first_indexed | 2024-12-12T14:44:12Z |
| format | Article |
| id | doaj.art-394b9bfce03a460c9360a3b37a2d6bae |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-12T14:44:12Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-394b9bfce03a460c9360a3b37a2d6bae2022-12-22T00:21:09ZengWileyCancer Medicine2045-76342022-05-011191984199410.1002/cam4.4502Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic RepublicPhimpha Paboriboune0Keokedthong Phongsavan1Phetsamone Arounlangsy2Bruno Flaissier3Oukham Aphayarath4Prasit Phimmasone5Ketmala Banchongphanith6Mixi Xayaovong7Gonzague Jourdain8Anne‐Marie Schott9Mitra Saadatian‐Elahi10Laurent Magaud11Amna Klich12Nicole Ngo‐Giang‐Huong13Isabelle Heard14Muriel Rabilloud15Valentina Sanchez Picot16Christophe Longuet17Centre d'Infectiologie Christophe Mérieux (CICML) Vientiane Lao‐PDRSetthatirath Hospital Vientiane Lao‐PDRPublic Health Science University Vientiane Lao‐PDRFondation Mérieux Phu Phanang National Bio‐Diversity Vientiane Lao‐PDRHIV Center Setthathirath Hospital Vientiane Lao‐PDRHIV Center Mahosot Hospital Vientiane Lao‐PDRNational Center for HIV/AIDS and STI Vientiane Lao‐PDRCentre d'Infectiologie Christophe Mérieux (CICML) Vientiane Lao‐PDRFrench National Research Institute for Sustainable Development (IRD) Marseille FranceUniversité Claude Bernard Lyon 1 Villeurbanne FranceService Hygiène Epidémiologie Infectiovigilance et Prévention Centre Hospitalier Edouard Herriot Hospices Civils de Lyon Lyon FranceHospices Civils de Lyon Pole Santé Publique Lyon FranceUniversité de Lyon Lyon FranceFrench National Research Institute for Sustainable Development (IRD) Marseille FranceFrench National Human papillomavirus Reference Laboratory Institut Pasteur Paris FranceUniversité de Lyon Lyon FranceFondation Mérieux Lyon FranceFondation Mérieux Lyon FranceAbstract Background In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims The objective of this cross‐sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid‐based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV‐1). Materials & Methods Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid‐based cytology, careHPV™ test, and HPV‐16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests. Results Of the 631 women with follow‐up, 331 were human papillomavirus (HPV) negative. High‐grade squamous intraepithelial lesions were found in 37 women, biopsy‐proven high‐grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high‐grade cervical lesion or carcinoma detected after abnormal careHPV™ test was higher (6.02%; 95% confidence interval [CI]: 4.4–8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2–6.5). careHPV™ and HPV‐16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4–89.5) and specificity (92.2%; 95% CI: 89.8–94.2). HPV‐16 was the most frequently detected genotype. Conclusions careHPV™ test represents a screening option in Lao PDR, particularly in women living with HIV‐1 because of higher prevalence of chronic HPV in this population.https://doi.org/10.1002/cam4.4502careHPV™cervical cancerHIV‐1Lao PDRliquid‐based cytologyPapanicolaou test |
| spellingShingle | Phimpha Paboriboune Keokedthong Phongsavan Phetsamone Arounlangsy Bruno Flaissier Oukham Aphayarath Prasit Phimmasone Ketmala Banchongphanith Mixi Xayaovong Gonzague Jourdain Anne‐Marie Schott Mitra Saadatian‐Elahi Laurent Magaud Amna Klich Nicole Ngo‐Giang‐Huong Isabelle Heard Muriel Rabilloud Valentina Sanchez Picot Christophe Longuet Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic Cancer Medicine careHPV™ cervical cancer HIV‐1 Lao PDR liquid‐based cytology Papanicolaou test |
| title | Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic |
| title_full | Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic |
| title_fullStr | Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic |
| title_full_unstemmed | Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic |
| title_short | Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic |
| title_sort | efficacy of carehpv™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with hiv 1 in lao people s democratic republic |
| topic | careHPV™ cervical cancer HIV‐1 Lao PDR liquid‐based cytology Papanicolaou test |
| url | https://doi.org/10.1002/cam4.4502 |
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