Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center
Objectives: The aim of the study was to evaluate the efficacy of early initiation versus late growth hormone in improving the predicted adult height in growth hormone deficiency (GHD) children. Methods: A retrospective study of 550 GHD children with short stature, who had taken rGH for duration of m...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=1;spage=54;epage=58;aulast=Kochar |
| _version_ | 1818457196884656128 |
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| author | Inderpal S Kochar Smita Ramachandran Aashish Sethi |
| author_facet | Inderpal S Kochar Smita Ramachandran Aashish Sethi |
| author_sort | Inderpal S Kochar |
| collection | DOAJ |
| description | Objectives: The aim of the study was to evaluate the efficacy of early initiation versus late growth hormone in improving the predicted adult height in growth hormone deficiency (GHD) children. Methods: A retrospective study of 550 GHD children with short stature, who had taken rGH for duration of minimum 12 months were included. They were divided into groups of less than 8 years and more than 8 years of age based on the initiation of growth hormone therapy. Their pretreatment and post-treatment auxological parameters were evaluated. Results: There were 148 children in less than 8 years group and 402 children in more than 8 years old group. In 8 years or younger age group, the pre-treatment mean height of –2.015 SDS improved to –0.7753 SDS after one year of treatment. There was an improvement in the mean height from –2.0447 SDS to –1.2658 SDS post-treatment in more than 8 years group. The pre- and post-treatment difference between the Z score of height, weight, and BMI were statistically significant (<0.001). Conclusion: A significant height improvement occurred in both the groups' children after 1 year of GH treatment but the gain in final adult height was better when initiated less than 8 years of age. No significant side effects were noted during this period. |
| first_indexed | 2024-12-14T22:38:44Z |
| format | Article |
| id | doaj.art-394c8440d9a747ce9e4e145ffe92b512 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-14T22:38:44Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-394c8440d9a747ce9e4e145ffe92b5122022-12-21T22:45:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102021-01-01251545810.4103/ijem.IJEM_739_20Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care centerInderpal S KocharSmita RamachandranAashish SethiObjectives: The aim of the study was to evaluate the efficacy of early initiation versus late growth hormone in improving the predicted adult height in growth hormone deficiency (GHD) children. Methods: A retrospective study of 550 GHD children with short stature, who had taken rGH for duration of minimum 12 months were included. They were divided into groups of less than 8 years and more than 8 years of age based on the initiation of growth hormone therapy. Their pretreatment and post-treatment auxological parameters were evaluated. Results: There were 148 children in less than 8 years group and 402 children in more than 8 years old group. In 8 years or younger age group, the pre-treatment mean height of –2.015 SDS improved to –0.7753 SDS after one year of treatment. There was an improvement in the mean height from –2.0447 SDS to –1.2658 SDS post-treatment in more than 8 years group. The pre- and post-treatment difference between the Z score of height, weight, and BMI were statistically significant (<0.001). Conclusion: A significant height improvement occurred in both the groups' children after 1 year of GH treatment but the gain in final adult height was better when initiated less than 8 years of age. No significant side effects were noted during this period.http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=1;spage=54;epage=58;aulast=Kocharindian childrengrowth hormone deficiencyshort stature |
| spellingShingle | Inderpal S Kochar Smita Ramachandran Aashish Sethi Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center Indian Journal of Endocrinology and Metabolism indian children growth hormone deficiency short stature |
| title | Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center |
| title_full | Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center |
| title_fullStr | Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center |
| title_full_unstemmed | Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center |
| title_short | Effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children: Experience from an Indian tertiary care center |
| title_sort | effects of early initiation of growth hormone therapy on different auxological parameters in growth hormone deficient children experience from an indian tertiary care center |
| topic | indian children growth hormone deficiency short stature |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=1;spage=54;epage=58;aulast=Kochar |
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