Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances
<p>Abstract</p> <p>Background</p> <p>Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC). The study was carried out to investigate the correlations...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-12-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://www.wjso.com/content/9/1/158 |
| _version_ | 1818787446290120704 |
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| author | Ren Juchao Liu Hainan Yan Lei Tian Sujian Li Dawei Xu Zhonghua |
| author_facet | Ren Juchao Liu Hainan Yan Lei Tian Sujian Li Dawei Xu Zhonghua |
| author_sort | Ren Juchao |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC). The study was carried out to investigate the correlations between microvessel density (MVD) and heparanase expression containing prognostic significances in the patients with ccRCC.</p> <p>Methods</p> <p>Specimens from 128 patients with ccRCC were investigated by immunohistochemistry for MVD. RT-PCR and immunohistochemistry were used to detect heparanase expression. Correlations between MVD, heparanase expression, and various clinico-pathological factors were studied. The prognostic significances of MVD and heparanase expression were also analysed.</p> <p>Results</p> <p>We discovered a statistically significant prevalence of higher MVD in ccRCC compared with adjacent normal renal tissues. MVD was positively correlated with TNM stage and distant metastasis in ccRCC patients, and was also correlated with the expression level of heparanase.</p> <p>Heparanase is over-expressed and correlated with TNM stage, histologic grade, distant metastasis and lymphatic metastasis in ccRCC. High MVD and heparanase over-expression inversely correlate with the survival of ccRCC patients.</p> <p>Conclusions</p> <p>Heparanase contributes to angiogenesis of ccRCC and over-expression of heparanase is an independent predictors of prognosis for ccRCC. MVD is correlated with tumor development and metastasis in ccRCC.</p> |
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| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-18T14:07:54Z |
| publishDate | 2011-12-01 |
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| series | World Journal of Surgical Oncology |
| spelling | doaj.art-394ca9cbb03a4df5acbedd61a56241a92022-12-21T21:05:12ZengBMCWorld Journal of Surgical Oncology1477-78192011-12-019115810.1186/1477-7819-9-158Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significancesRen JuchaoLiu HainanYan LeiTian SujianLi DaweiXu Zhonghua<p>Abstract</p> <p>Background</p> <p>Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC). The study was carried out to investigate the correlations between microvessel density (MVD) and heparanase expression containing prognostic significances in the patients with ccRCC.</p> <p>Methods</p> <p>Specimens from 128 patients with ccRCC were investigated by immunohistochemistry for MVD. RT-PCR and immunohistochemistry were used to detect heparanase expression. Correlations between MVD, heparanase expression, and various clinico-pathological factors were studied. The prognostic significances of MVD and heparanase expression were also analysed.</p> <p>Results</p> <p>We discovered a statistically significant prevalence of higher MVD in ccRCC compared with adjacent normal renal tissues. MVD was positively correlated with TNM stage and distant metastasis in ccRCC patients, and was also correlated with the expression level of heparanase.</p> <p>Heparanase is over-expressed and correlated with TNM stage, histologic grade, distant metastasis and lymphatic metastasis in ccRCC. High MVD and heparanase over-expression inversely correlate with the survival of ccRCC patients.</p> <p>Conclusions</p> <p>Heparanase contributes to angiogenesis of ccRCC and over-expression of heparanase is an independent predictors of prognosis for ccRCC. MVD is correlated with tumor development and metastasis in ccRCC.</p>http://www.wjso.com/content/9/1/158clear cell renal cell carcinomamicrovessel densityheparanaseprognosis |
| spellingShingle | Ren Juchao Liu Hainan Yan Lei Tian Sujian Li Dawei Xu Zhonghua Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances World Journal of Surgical Oncology clear cell renal cell carcinoma microvessel density heparanase prognosis |
| title | Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances |
| title_full | Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances |
| title_fullStr | Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances |
| title_full_unstemmed | Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances |
| title_short | Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances |
| title_sort | microvessel density and heparanase over expression in clear cell renal cell cancer correlations and prognostic significances |
| topic | clear cell renal cell carcinoma microvessel density heparanase prognosis |
| url | http://www.wjso.com/content/9/1/158 |
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