Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer
Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study add...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-11-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/1903 |
| _version_ | 1818028714661773312 |
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| author | F. Piras M.T. Ionta S. Lai M.T. Perra F. Atzori L. Minerba V. Pusceddu C. Maxia D. Murtas P. Demurtas B. Massidda P. Sirigu |
| author_facet | F. Piras M.T. Ionta S. Lai M.T. Perra F. Atzori L. Minerba V. Pusceddu C. Maxia D. Murtas P. Demurtas B. Massidda P. Sirigu |
| author_sort | F. Piras |
| collection | DOAJ |
| description | Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients’ outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers. |
| first_indexed | 2024-12-10T05:08:11Z |
| format | Article |
| id | doaj.art-394de536c1354f70b5878afc42c84ee7 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-10T05:08:11Z |
| publishDate | 2011-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-394de536c1354f70b5878afc42c84ee72022-12-22T02:01:10ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062011-11-01554e39e3910.4081/ejh.2011.e391231Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancerF. Piras0M.T. Ionta1S. Lai2M.T. Perra3F. Atzori4L. Minerba5V. Pusceddu6C. Maxia7D. Murtas8P. Demurtas9B. Massidda10P. Sirigu11University of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariUniversity of CagliariNestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients’ outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers.http://www.ejh.it/index.php/ejh/article/view/1903Nestin, T4 breast cancer, triple negative, prognosis |
| spellingShingle | F. Piras M.T. Ionta S. Lai M.T. Perra F. Atzori L. Minerba V. Pusceddu C. Maxia D. Murtas P. Demurtas B. Massidda P. Sirigu Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer European Journal of Histochemistry Nestin, T4 breast cancer, triple negative, prognosis |
| title | Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer |
| title_full | Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer |
| title_fullStr | Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer |
| title_full_unstemmed | Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer |
| title_short | Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer |
| title_sort | nestin expression associates with poor prognosis and triple negative phenotype in locally advanced t4 breast cancer |
| topic | Nestin, T4 breast cancer, triple negative, prognosis |
| url | http://www.ejh.it/index.php/ejh/article/view/1903 |
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