Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region
Surgical site infection (SSI) following caesarean section is associated with increased morbidity, mortality, and significant health care costs. This study evaluated the epidemiological, clinical, and microbiological features of <i>Acinetobacter</i> spp. in women with SSIs who have underg...
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/4/743 |
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| author | Blenda Gonçalves Cabral Danielle Murici Brasiliense Ismari Perini Furlaneto Yan Corrêa Rodrigues Karla Valéria Batista Lima |
| author_facet | Blenda Gonçalves Cabral Danielle Murici Brasiliense Ismari Perini Furlaneto Yan Corrêa Rodrigues Karla Valéria Batista Lima |
| author_sort | Blenda Gonçalves Cabral |
| collection | DOAJ |
| description | Surgical site infection (SSI) following caesarean section is associated with increased morbidity, mortality, and significant health care costs. This study evaluated the epidemiological, clinical, and microbiological features of <i>Acinetobacter</i> spp. in women with SSIs who have undergone caesarean section at a referral hospital in the Brazilian Amazon region. This study included 69 women with post-caesarean SSI by <i>Acinetobacter</i> spp. admitted to the hospital between January 2012 and May 2015. The 69 <i>Acinetobacter</i> isolates were subjected to molecular species identification, antimicrobial susceptibility testing, detection of carbapenemase-encoding genes, and genotyping. The main complications of post-caesarean SSI by <i>Acinetobacter</i> were inadequate and prolonged antibiotic therapy, sepsis, prolonged hospitalization, and re-suture procedures. <i>A. baumannii</i>, <i>A. nosocomialis</i> and <i>A. colistiniresistens</i> species were identified among the isolates. Carbapenem resistance was associated with OXA-23-producing <i>A. baumannii</i> isolates and IMP-1-producing <i>A. nosocomialis</i> isolate. Patients with multidrug-resistant <i>A. baumannii</i> infection showed worse clinical courses. Dissemination of persistent epidemic clones was observed, and the main clonal complexes (CC) for <i>A. baumannii</i> were CC231 and CC236 (Oxford scheme) and CC1 and CC15 (Pasteur scheme). This is the first report of a long-term <i>Acinetobacter</i> spp. outbreak in women who underwent caesarean section at a Brazilian hospital. This study demonstrates the impact of multidrug resistance on the clinical course of post-caesarean infections. |
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| id | doaj.art-394e03a3f6a446598516d1e93b5e54f8 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T12:40:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-394e03a3f6a446598516d1e93b5e54f82023-11-21T13:56:30ZengMDPI AGMicroorganisms2076-26072021-04-019474310.3390/microorganisms9040743Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon RegionBlenda Gonçalves Cabral0Danielle Murici Brasiliense1Ismari Perini Furlaneto2Yan Corrêa Rodrigues3Karla Valéria Batista Lima4Parasitic Biology in the Amazon Region, Center of Biological and Health Sciences, State University of Pará, Belém 66087-662, PA, BrazilBacteriology and Mycology Section, Evandro Chagas Institute, Ananindeua 67030-000, PA, BrazilHealth Education, University Center of Pará, Belém 66613-903, PA, BrazilParasitic Biology in the Amazon Region, Center of Biological and Health Sciences, State University of Pará, Belém 66087-662, PA, BrazilParasitic Biology in the Amazon Region, Center of Biological and Health Sciences, State University of Pará, Belém 66087-662, PA, BrazilSurgical site infection (SSI) following caesarean section is associated with increased morbidity, mortality, and significant health care costs. This study evaluated the epidemiological, clinical, and microbiological features of <i>Acinetobacter</i> spp. in women with SSIs who have undergone caesarean section at a referral hospital in the Brazilian Amazon region. This study included 69 women with post-caesarean SSI by <i>Acinetobacter</i> spp. admitted to the hospital between January 2012 and May 2015. The 69 <i>Acinetobacter</i> isolates were subjected to molecular species identification, antimicrobial susceptibility testing, detection of carbapenemase-encoding genes, and genotyping. The main complications of post-caesarean SSI by <i>Acinetobacter</i> were inadequate and prolonged antibiotic therapy, sepsis, prolonged hospitalization, and re-suture procedures. <i>A. baumannii</i>, <i>A. nosocomialis</i> and <i>A. colistiniresistens</i> species were identified among the isolates. Carbapenem resistance was associated with OXA-23-producing <i>A. baumannii</i> isolates and IMP-1-producing <i>A. nosocomialis</i> isolate. Patients with multidrug-resistant <i>A. baumannii</i> infection showed worse clinical courses. Dissemination of persistent epidemic clones was observed, and the main clonal complexes (CC) for <i>A. baumannii</i> were CC231 and CC236 (Oxford scheme) and CC1 and CC15 (Pasteur scheme). This is the first report of a long-term <i>Acinetobacter</i> spp. outbreak in women who underwent caesarean section at a Brazilian hospital. This study demonstrates the impact of multidrug resistance on the clinical course of post-caesarean infections.https://www.mdpi.com/2076-2607/9/4/743caesareansurgical site infection<i>Acinetobacter</i>clonal complexes |
| spellingShingle | Blenda Gonçalves Cabral Danielle Murici Brasiliense Ismari Perini Furlaneto Yan Corrêa Rodrigues Karla Valéria Batista Lima Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region Microorganisms caesarean surgical site infection <i>Acinetobacter</i> clonal complexes |
| title | Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region |
| title_full | Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region |
| title_fullStr | Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region |
| title_full_unstemmed | Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region |
| title_short | Surgical Site Infection Following Caesarean Section by <i>Acinetobacter</i> Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region |
| title_sort | surgical site infection following caesarean section by i acinetobacter i species a report from a hyperendemic setting in the brazilian amazon region |
| topic | caesarean surgical site infection <i>Acinetobacter</i> clonal complexes |
| url | https://www.mdpi.com/2076-2607/9/4/743 |
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