Macrophages as drivers of an opportunistic infection
Opportunistic pathogens are a worldwide cause of mortality and morbidity, and infections with intrinsically antibiotic-resistant pathogens have a large clinical, social and economic impact. Bacteria belonging to the Burkholderia cepacia complex (Bcc), ubiquitous in natural and industrial environment...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2017-09-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/macrophages-as-drivers-of-an-opportunistic-infection/ |
| _version_ | 1819099232725893120 |
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| author | Annette C. Vergunst Nazareth Lopez Carranza Lili Zhang Margarida C. Gomes Yara Tasrini Annemarie H. Meijer David O’Callaghan |
| author_facet | Annette C. Vergunst Nazareth Lopez Carranza Lili Zhang Margarida C. Gomes Yara Tasrini Annemarie H. Meijer David O’Callaghan |
| author_sort | Annette C. Vergunst |
| collection | DOAJ |
| description | Opportunistic pathogens are a worldwide cause of mortality and morbidity, and infections with intrinsically antibiotic-resistant pathogens have a large clinical, social and economic impact. Bacteria belonging to the Burkholderia cepacia complex (Bcc), ubiquitous in natural and industrial environments, are notorious pathogens for individuals with cystic fibrosis (CF). In addition, Burkholderia cenocepacia is emerging as the culprit of non-CF related, sometimes fatal infections. Knowledge of the underlying infection mechanism of these pathogens is important for efficient treatment, however, to date not much is known about the lifestyle of Bcc bacteria during infection. In our recent study published in PLoS Pathogens, we provide experimental evidence that macrophages are critically important for proliferation of B. cenocepacia, and are major drivers of fatal pro-inflammatory infections in zebrafish larvae. This is in agreement with recent clinical information showing that B. cenocepacia is mainly localised in phagocytes in infected CF lungs. A predominant intramacrophage stage and a host-detrimental role for macrophages have major implications for treatment strategies of both CF and non-CF infections. Intracellular survival of bacteria traditionally classified as extracellular, including Staphylococcus aureus and Pseudomonas aeruginosa, is an emerging theme. Our finding that macrophages are essential for proliferation of B. cenocepacia in the host suggests a new paradigm for Bcc infections and urges the development of novel anti-infectious therapies to efficiently disarm these intrinsically antibiotic resistant facultative intracellular pathogens. |
| first_indexed | 2024-12-22T00:43:37Z |
| format | Article |
| id | doaj.art-394e137dfb6c45738e33b95d66189874 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-22T00:43:37Z |
| publishDate | 2017-09-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-394e137dfb6c45738e33b95d661898742022-12-21T18:44:37ZengShared Science Publishers OGMicrobial Cell2311-26382017-09-0141036236410.15698/mic2017.10.595Macrophages as drivers of an opportunistic infectionAnnette C. Vergunst0Nazareth Lopez Carranza1Lili Zhang2Margarida C. Gomes3Yara Tasrini4Annemarie H. Meijer5David O’Callaghan6Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.Opportunistic pathogens are a worldwide cause of mortality and morbidity, and infections with intrinsically antibiotic-resistant pathogens have a large clinical, social and economic impact. Bacteria belonging to the Burkholderia cepacia complex (Bcc), ubiquitous in natural and industrial environments, are notorious pathogens for individuals with cystic fibrosis (CF). In addition, Burkholderia cenocepacia is emerging as the culprit of non-CF related, sometimes fatal infections. Knowledge of the underlying infection mechanism of these pathogens is important for efficient treatment, however, to date not much is known about the lifestyle of Bcc bacteria during infection. In our recent study published in PLoS Pathogens, we provide experimental evidence that macrophages are critically important for proliferation of B. cenocepacia, and are major drivers of fatal pro-inflammatory infections in zebrafish larvae. This is in agreement with recent clinical information showing that B. cenocepacia is mainly localised in phagocytes in infected CF lungs. A predominant intramacrophage stage and a host-detrimental role for macrophages have major implications for treatment strategies of both CF and non-CF infections. Intracellular survival of bacteria traditionally classified as extracellular, including Staphylococcus aureus and Pseudomonas aeruginosa, is an emerging theme. Our finding that macrophages are essential for proliferation of B. cenocepacia in the host suggests a new paradigm for Bcc infections and urges the development of novel anti-infectious therapies to efficiently disarm these intrinsically antibiotic resistant facultative intracellular pathogens.http://microbialcell.com/researcharticles/macrophages-as-drivers-of-an-opportunistic-infection/Burkholderia cenocepaciamacrophagesintracellular bacteriabiofilmsopportunistic infectionscystic fibrosiszebrafishnosocomial infections |
| spellingShingle | Annette C. Vergunst Nazareth Lopez Carranza Lili Zhang Margarida C. Gomes Yara Tasrini Annemarie H. Meijer David O’Callaghan Macrophages as drivers of an opportunistic infection Microbial Cell Burkholderia cenocepacia macrophages intracellular bacteria biofilms opportunistic infections cystic fibrosis zebrafish nosocomial infections |
| title | Macrophages as drivers of an opportunistic infection |
| title_full | Macrophages as drivers of an opportunistic infection |
| title_fullStr | Macrophages as drivers of an opportunistic infection |
| title_full_unstemmed | Macrophages as drivers of an opportunistic infection |
| title_short | Macrophages as drivers of an opportunistic infection |
| title_sort | macrophages as drivers of an opportunistic infection |
| topic | Burkholderia cenocepacia macrophages intracellular bacteria biofilms opportunistic infections cystic fibrosis zebrafish nosocomial infections |
| url | http://microbialcell.com/researcharticles/macrophages-as-drivers-of-an-opportunistic-infection/ |
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