Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature
Background: Epithelial myoepithelial carcinoma (EMC) is a rare biphasic tumour of the salivary gland with two cell types of inner ductal cells and outer layer of clear cells. In the literature, there are only a few reports of EMC originating from the hard palate. Case report: A 58-year-old female p...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2019-11-01
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| Series: | European Medical Journal Oncology |
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| Online Access: | https://www.emjreviews.com/oncology/article/epithelial-myoepithelial-carcinoma-of-the-hard-palate-a-case-report-with-a-review-of-the-literature/ |
| _version_ | 1818280296414445568 |
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| author | Ravisankar Palaniappan Jayanthi Chandran Damodarakumaran Purushothaman Vijayaraghavan Nandhagopal |
| author_facet | Ravisankar Palaniappan Jayanthi Chandran Damodarakumaran Purushothaman Vijayaraghavan Nandhagopal |
| author_sort | Ravisankar Palaniappan |
| collection | DOAJ |
| description | Background: Epithelial myoepithelial carcinoma (EMC) is a rare biphasic tumour of the salivary gland with two cell types of inner ductal cells and outer layer of clear cells. In the literature, there are only a few reports of EMC originating from the hard palate.
Case report: A 58-year-old female presented to the authors’ institution with partially submucosal lesion in the posterior aspect of the hard palate on the left side for 1 month. Biopsy was suggestive of a multinodular tumour with round to oval cells and a moderate number of pale eosinophilic to clear cytoplasm and round to oval, centrally to eccentrically placed, mildly pleomorphic vesicular nuclei suggestive of EMC of the hard palate. Immunohistochemically, cytokeratin (CK 5/6) showed strong cytoplasmic positivity highlighting the luminal epithelial cells. The myoepithelial cells showed strong nuclear positivity for p63 and cytoplasmic positivity for calponin. The patient underwent surgical resection of the tumour with a local flap cover and split skin graft and all the margins were negative in the final histopathological examination with erosion of the underlying bone. The patient was kept under observation and has been free of the disease for the past 12 months.
Conclusion: Diagnosis of EMC is rare and is to be kept as a differential diagnosis during the evaluation of minor salivary gland tumours of palate. |
| first_indexed | 2024-12-12T23:46:58Z |
| format | Article |
| id | doaj.art-394e5572177e4f7299457c147cbb7d0f |
| institution | Directory Open Access Journal |
| issn | 2054-619X |
| language | English |
| last_indexed | 2024-12-12T23:46:58Z |
| publishDate | 2019-11-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Oncology |
| spelling | doaj.art-394e5572177e4f7299457c147cbb7d0f2022-12-22T00:06:48ZengEuropean Medical JournalEuropean Medical Journal Oncology2054-619X2019-11-01716367Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the LiteratureRavisankar Palaniappan0Jayanthi Chandran1Damodarakumaran Purushothaman2Vijayaraghavan Nandhagopal3Department of Surgical Oncology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Pondicherry, IndiaDepartment of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, IndiaDepartment of Radiation Oncology, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, IndiaDepartment of Plastic and Reconstructive Surgery, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, IndiaBackground: Epithelial myoepithelial carcinoma (EMC) is a rare biphasic tumour of the salivary gland with two cell types of inner ductal cells and outer layer of clear cells. In the literature, there are only a few reports of EMC originating from the hard palate. Case report: A 58-year-old female presented to the authors’ institution with partially submucosal lesion in the posterior aspect of the hard palate on the left side for 1 month. Biopsy was suggestive of a multinodular tumour with round to oval cells and a moderate number of pale eosinophilic to clear cytoplasm and round to oval, centrally to eccentrically placed, mildly pleomorphic vesicular nuclei suggestive of EMC of the hard palate. Immunohistochemically, cytokeratin (CK 5/6) showed strong cytoplasmic positivity highlighting the luminal epithelial cells. The myoepithelial cells showed strong nuclear positivity for p63 and cytoplasmic positivity for calponin. The patient underwent surgical resection of the tumour with a local flap cover and split skin graft and all the margins were negative in the final histopathological examination with erosion of the underlying bone. The patient was kept under observation and has been free of the disease for the past 12 months. Conclusion: Diagnosis of EMC is rare and is to be kept as a differential diagnosis during the evaluation of minor salivary gland tumours of palate.https://www.emjreviews.com/oncology/article/epithelial-myoepithelial-carcinoma-of-the-hard-palate-a-case-report-with-a-review-of-the-literature/case reportepithelial myoepithelial carcinoma (emc)hard palate |
| spellingShingle | Ravisankar Palaniappan Jayanthi Chandran Damodarakumaran Purushothaman Vijayaraghavan Nandhagopal Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature European Medical Journal Oncology case report epithelial myoepithelial carcinoma (emc) hard palate |
| title | Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature |
| title_full | Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature |
| title_fullStr | Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature |
| title_full_unstemmed | Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature |
| title_short | Epithelial Myoepithelial Carcinoma of the Hard Palate: A Case Report with a Review of the Literature |
| title_sort | epithelial myoepithelial carcinoma of the hard palate a case report with a review of the literature |
| topic | case report epithelial myoepithelial carcinoma (emc) hard palate |
| url | https://www.emjreviews.com/oncology/article/epithelial-myoepithelial-carcinoma-of-the-hard-palate-a-case-report-with-a-review-of-the-literature/ |
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