Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Persistent virus infection continuously produces non-self nucleic acids that activate cell-intrinsic immune responses. However, the antiviral defense evolved as a transient, acute phase response and the effects of persistently ongoing stimulation onto cellular homeostasis are not well understood. To...

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Bibliographic Details
Main Authors: Christian Urban, Hendrik Welsch, Katharina Heine, Sandra Wüst, Darya A. Haas, Christopher Dächert, Aparna Pandey, Andreas Pichlmair, Marco Binder
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
innate immunity
RIG-I
MAVS
IRF3
interferon
HCV
Online Access:https://www.mdpi.com/1999-4915/12/6/635

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