Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort
BackgroundAcute coronary syndrome (ACS) in early adulthood (<40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome might have antecedent Kawasaki disease in a cohort with Kawa...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167771/full |
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| author | Tsung-Cheng Shyu Tsung-Cheng Shyu Chiung-Jen Wu Yun-Ching Fu Yi-Chin Peng Yi-Chin Peng Tzu-Yao Chuang Tzu-Yao Chuang Ho-Chang Kuo Kai-Sheng Hsieh Kai-Sheng Hsieh I-Hsin Tai I-Hsin Tai |
| author_facet | Tsung-Cheng Shyu Tsung-Cheng Shyu Chiung-Jen Wu Yun-Ching Fu Yi-Chin Peng Yi-Chin Peng Tzu-Yao Chuang Tzu-Yao Chuang Ho-Chang Kuo Kai-Sheng Hsieh Kai-Sheng Hsieh I-Hsin Tai I-Hsin Tai |
| author_sort | Tsung-Cheng Shyu |
| collection | DOAJ |
| description | BackgroundAcute coronary syndrome (ACS) in early adulthood (<40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome might have antecedent Kawasaki disease in a cohort with Kawasaki disease incidence rates ranging from about 9 to 20 per 100,000 children under 5 years of age. However, there is no relevant research from the cohort with higher incidence rates (>80–100 per 100,000 children under 5 years of age) of Kawasaki disease.MethodsWe conducted a multicenter, retrospective study by reviewing medical records and angiographic data from two institutions (middle and southern Taiwan, respectively) of adults <40 years of age who underwent coronary angiography for clinically suspected acute coronary syndrome (2009–2019). Angiographic images were independently analyzed by three cardiologists who were blinded to the medical records. Demographic and laboratory data and risk factors of coronary artery disease were integrated to assess the likelihood of antecedent KD.ResultsAll 323 young adults underwent coronary angiography, and 27 had coronary aneurysms. The patients’ clinical and angiographic characteristics were evaluated, and 7.4% had aneurysms likely to be associated with KD. Most subjects were male (23/24), and their low-density lipoprotein (LDL) levels were significantly higher (p = 0.028) than those of subjects unlikely to have KD.ConclusionThis study proposed that the cohort with higher Kawasaki disease incidence rates may have a higher prevalence of young adult ACS associated with antecedent KD. The importance of determining the clinical therapeutic significance of antecedent Kawasaki disease in young adult ACS warrants advanced research. Higher LDL levels may have a long-term cardiovascular impact in KD patients with persistent coronary aneurysms. |
| first_indexed | 2024-03-12T17:34:25Z |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T17:34:25Z |
| publishDate | 2023-08-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-394f72d0516f4ac39eeda32c9aa3e4732023-08-04T12:20:33ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-08-011010.3389/fcvm.2023.11677711167771Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohortTsung-Cheng Shyu0Tsung-Cheng Shyu1Chiung-Jen Wu2Yun-Ching Fu3Yi-Chin Peng4Yi-Chin Peng5Tzu-Yao Chuang6Tzu-Yao Chuang7Ho-Chang Kuo8Kai-Sheng Hsieh9Kai-Sheng Hsieh10I-Hsin Tai11I-Hsin Tai12Department of Pediatric Cardiology, Structural/Congenital Heart Disease and Echocardiography Center, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung, TaiwanDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, TaiwanDepartment of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatric Cardiology, Structural/Congenital Heart Disease and Echocardiography Center, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung, TaiwanDepartment of Pediatric Cardiology, Structural/Congenital Heart Disease and Echocardiography Center, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung, TaiwanKawasaki Disease Center and Pediatrics, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, TaiwanDepartment of Pediatric Cardiology, Structural/Congenital Heart Disease and Echocardiography Center, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung, TaiwanDepartment of Pediatric Cardiology, Structural/Congenital Heart Disease and Echocardiography Center, China Medical University Children’s Hospital, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung, TaiwanBackgroundAcute coronary syndrome (ACS) in early adulthood (<40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome might have antecedent Kawasaki disease in a cohort with Kawasaki disease incidence rates ranging from about 9 to 20 per 100,000 children under 5 years of age. However, there is no relevant research from the cohort with higher incidence rates (>80–100 per 100,000 children under 5 years of age) of Kawasaki disease.MethodsWe conducted a multicenter, retrospective study by reviewing medical records and angiographic data from two institutions (middle and southern Taiwan, respectively) of adults <40 years of age who underwent coronary angiography for clinically suspected acute coronary syndrome (2009–2019). Angiographic images were independently analyzed by three cardiologists who were blinded to the medical records. Demographic and laboratory data and risk factors of coronary artery disease were integrated to assess the likelihood of antecedent KD.ResultsAll 323 young adults underwent coronary angiography, and 27 had coronary aneurysms. The patients’ clinical and angiographic characteristics were evaluated, and 7.4% had aneurysms likely to be associated with KD. Most subjects were male (23/24), and their low-density lipoprotein (LDL) levels were significantly higher (p = 0.028) than those of subjects unlikely to have KD.ConclusionThis study proposed that the cohort with higher Kawasaki disease incidence rates may have a higher prevalence of young adult ACS associated with antecedent KD. The importance of determining the clinical therapeutic significance of antecedent Kawasaki disease in young adult ACS warrants advanced research. Higher LDL levels may have a long-term cardiovascular impact in KD patients with persistent coronary aneurysms.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167771/fullKawasaki disease (KD)prevalenceacute coronary syndromecoronary aneurysmlow-density lipoproteinyoung adult |
| spellingShingle | Tsung-Cheng Shyu Tsung-Cheng Shyu Chiung-Jen Wu Yun-Ching Fu Yi-Chin Peng Yi-Chin Peng Tzu-Yao Chuang Tzu-Yao Chuang Ho-Chang Kuo Kai-Sheng Hsieh Kai-Sheng Hsieh I-Hsin Tai I-Hsin Tai Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort Frontiers in Cardiovascular Medicine Kawasaki disease (KD) prevalence acute coronary syndrome coronary aneurysm low-density lipoprotein young adult |
| title | Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| title_full | Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| title_fullStr | Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| title_full_unstemmed | Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| title_short | Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| title_sort | prevalence of antecedent kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort |
| topic | Kawasaki disease (KD) prevalence acute coronary syndrome coronary aneurysm low-density lipoprotein young adult |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167771/full |
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