The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement
Summary: Cerebellar-thalamo-striatal synaptic communication has been implicated in a wide range of behaviors, including goal-directed actions, and is altered in cerebellar dystonia. However, its detailed connectivity through the thalamus and its contribution to the execution of forelimb movements is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723000116 |
| _version_ | 1797947039514886144 |
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| author | Rubén Contreras-López Hector Alatriste-León Edgar Díaz-Hernández Josué O. Ramírez-Jarquín Fatuel Tecuapetla |
| author_facet | Rubén Contreras-López Hector Alatriste-León Edgar Díaz-Hernández Josué O. Ramírez-Jarquín Fatuel Tecuapetla |
| author_sort | Rubén Contreras-López |
| collection | DOAJ |
| description | Summary: Cerebellar-thalamo-striatal synaptic communication has been implicated in a wide range of behaviors, including goal-directed actions, and is altered in cerebellar dystonia. However, its detailed connectivity through the thalamus and its contribution to the execution of forelimb movements is unclear. Here, we use trans-synaptic and retrograde tracing, ex vivo slice recordings, and optogenetic inhibitions during the execution of unidirectional or sequential joystick displacements to demonstrate that the deep cerebellar nuclei (DCN) influence the dorsal striatum with a very high probability. We show that this mainly occurs through the centrolateral (CL), parafascicular (PF), and ventrolateral (VL) nuclei of the thalamus, observing that the DCN→VL and DCN→CL pathways contribute to the execution of unidirectional forelimb displacements while the DCN→PF and DCN→thalamo→striatal pathways contribute to the appropriate execution of forelimb reaching and sequential displacements. These findings highlight specific contributions of the different cerebellar-thalamo-striatal paths to the control of skilled forelimb movement. |
| first_indexed | 2024-04-10T21:21:31Z |
| format | Article |
| id | doaj.art-394f9c541582448c8aac07bb64997086 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T21:21:31Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-394f9c541582448c8aac07bb649970862023-01-20T04:24:39ZengElsevierCell Reports2211-12472023-01-01421112000The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movementRubén Contreras-López0Hector Alatriste-León1Edgar Díaz-Hernández2Josué O. Ramírez-Jarquín3Fatuel Tecuapetla4Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, MexicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico; Corresponding authorSummary: Cerebellar-thalamo-striatal synaptic communication has been implicated in a wide range of behaviors, including goal-directed actions, and is altered in cerebellar dystonia. However, its detailed connectivity through the thalamus and its contribution to the execution of forelimb movements is unclear. Here, we use trans-synaptic and retrograde tracing, ex vivo slice recordings, and optogenetic inhibitions during the execution of unidirectional or sequential joystick displacements to demonstrate that the deep cerebellar nuclei (DCN) influence the dorsal striatum with a very high probability. We show that this mainly occurs through the centrolateral (CL), parafascicular (PF), and ventrolateral (VL) nuclei of the thalamus, observing that the DCN→VL and DCN→CL pathways contribute to the execution of unidirectional forelimb displacements while the DCN→PF and DCN→thalamo→striatal pathways contribute to the appropriate execution of forelimb reaching and sequential displacements. These findings highlight specific contributions of the different cerebellar-thalamo-striatal paths to the control of skilled forelimb movement.http://www.sciencedirect.com/science/article/pii/S2211124723000116CP: Neuroscience |
| spellingShingle | Rubén Contreras-López Hector Alatriste-León Edgar Díaz-Hernández Josué O. Ramírez-Jarquín Fatuel Tecuapetla The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement Cell Reports CP: Neuroscience |
| title | The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| title_full | The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| title_fullStr | The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| title_full_unstemmed | The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| title_short | The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| title_sort | deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723000116 |
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