Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008
Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2012-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/18/1/11-0533_article |
| _version_ | 1811217127383760896 |
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| author | Yolanda D. Sheppard Dean Middleton Yvonne Whitfield Felix Tyndel Shariq Haider Jamie Spiegelman Richard H. Swartz Mark P. Nelder Stacey L. Baker Lisa Landry Ross MacEachern Sherri Deamond Lorrie Ross Garth Peters Michelle Baird David Rose Greg Sanders John W. Austin |
| author_facet | Yolanda D. Sheppard Dean Middleton Yvonne Whitfield Felix Tyndel Shariq Haider Jamie Spiegelman Richard H. Swartz Mark P. Nelder Stacey L. Baker Lisa Landry Ross MacEachern Sherri Deamond Lorrie Ross Garth Peters Michelle Baird David Rose Greg Sanders John W. Austin |
| author_sort | Yolanda D. Sheppard |
| collection | DOAJ |
| description | Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41–61 days), indicative of intestinal toxemia botulism. Patients’ clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient’s feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism. |
| first_indexed | 2024-04-12T06:50:08Z |
| format | Article |
| id | doaj.art-3956298625b64f53b60562e3bb2a19bc |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T06:50:08Z |
| publishDate | 2012-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3956298625b64f53b60562e3bb2a19bc2022-12-22T03:43:24ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-01-011811610.3201/eid1801.110533Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008Yolanda D. SheppardDean MiddletonYvonne WhitfieldFelix TyndelShariq HaiderJamie SpiegelmanRichard H. SwartzMark P. NelderStacey L. BakerLisa LandryRoss MacEachernSherri DeamondLorrie RossGarth PetersMichelle BairdDavid RoseGreg SandersJohn W. AustinFive cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41–61 days), indicative of intestinal toxemia botulism. Patients’ clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient’s feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism.https://wwwnc.cdc.gov/eid/article/18/1/11-0533_articleintestinal botulismCrohn diseaseClostridium botulinumbacteriaadult intestinal toxemia botulismCanada |
| spellingShingle | Yolanda D. Sheppard Dean Middleton Yvonne Whitfield Felix Tyndel Shariq Haider Jamie Spiegelman Richard H. Swartz Mark P. Nelder Stacey L. Baker Lisa Landry Ross MacEachern Sherri Deamond Lorrie Ross Garth Peters Michelle Baird David Rose Greg Sanders John W. Austin Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 Emerging Infectious Diseases intestinal botulism Crohn disease Clostridium botulinum bacteria adult intestinal toxemia botulism Canada |
| title | Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 |
| title_full | Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 |
| title_fullStr | Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 |
| title_full_unstemmed | Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 |
| title_short | Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008 |
| title_sort | intestinal toxemia botulism in 3 adults ontario canada 2006 2008 |
| topic | intestinal botulism Crohn disease Clostridium botulinum bacteria adult intestinal toxemia botulism Canada |
| url | https://wwwnc.cdc.gov/eid/article/18/1/11-0533_article |
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