Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report

Objective: Sperm donation and hormonal therapy with micro-Testicular Epididymal Sperm Extraction (TESE) for infertility from testicular failure might not always be available in some contexts. We report a successful embryo transfer from the patient-by ‘cumulative sperm collection’ strategy. Case rep...

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Main Authors: Nahathai Paktinun, Chartchai Srisombut, Thidarat Kongwattanasin, Krit Pongpirul
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2021-11-01
Series:Journal of Family and Reproductive Health
Subjects:
Online Access:https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1668
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author Nahathai Paktinun
Chartchai Srisombut
Thidarat Kongwattanasin
Krit Pongpirul
author_facet Nahathai Paktinun
Chartchai Srisombut
Thidarat Kongwattanasin
Krit Pongpirul
author_sort Nahathai Paktinun
collection DOAJ
description Objective: Sperm donation and hormonal therapy with micro-Testicular Epididymal Sperm Extraction (TESE) for infertility from testicular failure might not always be available in some contexts. We report a successful embryo transfer from the patient-by ‘cumulative sperm collection’ strategy. Case report: A 42 year-old male presented with non-obstructive azoospermia from testicular failure. Hormonal treatments were given along with the patient-initiated ‘cumulative sperm collection’ strategy, which eventually resulted in 17 sperms retrieved. Twelve mature oocytes were selected for intracytoplasmic sperm injection (ICSI) with the retrieved sperms, of which 8 oocytes were successfully fertilized but only two reached the early blastocyst stage; the first embryo transfer was not successful. Another five eggs were thawed and fertilized with the remaining 5 sperms and 3 oocytes were successfully fertilized: Seven cells were grade 3, 6 cells were grade 3, and 3 cells were grade 3. The second embryo transfer was successful, and the term female infant was successfully delivered by cesarean section. Conclusion: At a center without micro-TESE availability, successful embryo transfer for testicular failure type IV could be achieved by hormonal therapy plus a ‘cumulative sperm collection’ strategy.
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spelling doaj.art-3956918893b24b1f9cffa43a782ce47d2022-12-22T04:08:03ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922021-11-0115410.18502/jfrh.v15i4.7894Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case ReportNahathai Paktinun0Chartchai Srisombut1Thidarat Kongwattanasin2Krit Pongpirul3Bumrungrad International Hospital, Bangkok, ThailandBumrungrad International Hospital, Bangkok, ThailandBumrungrad International Hospital, Bangkok, ThailandBumrungrad International Hospital, Bangkok, Thailand AND Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand AND Johns Hopkins Bloomberg School of Public Health, Baltimore, USAObjective: Sperm donation and hormonal therapy with micro-Testicular Epididymal Sperm Extraction (TESE) for infertility from testicular failure might not always be available in some contexts. We report a successful embryo transfer from the patient-by ‘cumulative sperm collection’ strategy. Case report: A 42 year-old male presented with non-obstructive azoospermia from testicular failure. Hormonal treatments were given along with the patient-initiated ‘cumulative sperm collection’ strategy, which eventually resulted in 17 sperms retrieved. Twelve mature oocytes were selected for intracytoplasmic sperm injection (ICSI) with the retrieved sperms, of which 8 oocytes were successfully fertilized but only two reached the early blastocyst stage; the first embryo transfer was not successful. Another five eggs were thawed and fertilized with the remaining 5 sperms and 3 oocytes were successfully fertilized: Seven cells were grade 3, 6 cells were grade 3, and 3 cells were grade 3. The second embryo transfer was successful, and the term female infant was successfully delivered by cesarean section. Conclusion: At a center without micro-TESE availability, successful embryo transfer for testicular failure type IV could be achieved by hormonal therapy plus a ‘cumulative sperm collection’ strategy.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1668AzoospermiaHypogonadismSperm Retrieval
spellingShingle Nahathai Paktinun
Chartchai Srisombut
Thidarat Kongwattanasin
Krit Pongpirul
Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
Journal of Family and Reproductive Health
Azoospermia
Hypogonadism
Sperm Retrieval
title Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
title_full Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
title_fullStr Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
title_full_unstemmed Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
title_short Successful Treatment of Testicular Failure Type IV Without Micro-Testicular Epididymal Sperm Extraction: A Case Report
title_sort successful treatment of testicular failure type iv without micro testicular epididymal sperm extraction a case report
topic Azoospermia
Hypogonadism
Sperm Retrieval
url https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1668
work_keys_str_mv AT nahathaipaktinun successfultreatmentoftesticularfailuretypeivwithoutmicrotesticularepididymalspermextractionacasereport
AT chartchaisrisombut successfultreatmentoftesticularfailuretypeivwithoutmicrotesticularepididymalspermextractionacasereport
AT thidaratkongwattanasin successfultreatmentoftesticularfailuretypeivwithoutmicrotesticularepididymalspermextractionacasereport
AT kritpongpirul successfultreatmentoftesticularfailuretypeivwithoutmicrotesticularepididymalspermextractionacasereport