A spitting image: molecular diagnostics applied to saliva enhance detection of Streptococcus pneumoniae and pneumococcal serotype carriage

A spitting image: molecular diagnostics applied to saliva enhance detection of Streptococcus pneumoniae and pneumococcal serotype carriage

BackgroundDespite strong historical records on the accuracy of saliva testing, oral fluids are considered poorly suited for pneumococcal carriage detection. We evaluated an approach for carriage surveillance and vaccine studies that increases the sensitivity and specificity of pneumococcus and pneum...

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Bibliographic Details
Main Authors: Willem R. Miellet, Janieke van Veldhuizen, David Litt, Rob Mariman, Alienke J. Wijmenga-Monsuur, Tessa Nieuwenhuijsen, Jennifer Christopher, Rebecca Thombre, Seyi Eletu, Thijs Bosch, Nynke Y. Rots, Marianne Alice van Houten, Elizabeth Miller, Norman K. Fry, Elisabeth A. M. Sanders, Krzysztof Trzciński
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus pneumoniae (pneumococcus)
pneumococcal serotypes
pneumococcal carriage
saliva
quantitative PCR (qPCR)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1156695/full

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