Transmissible Cancers in an Evolutionary Perspective
Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine tr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220304557 |
| _version_ | 1819098764530417664 |
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| author | Antoine M. Dujon Robert A. Gatenby Georgina Bramwell Nick MacDonald Erin Dohrmann Nynke Raven Aaron Schultz Rodrigo Hamede Anne-Lise Gérard Mathieu Giraudeau Frédéric Thomas Beata Ujvari |
| author_facet | Antoine M. Dujon Robert A. Gatenby Georgina Bramwell Nick MacDonald Erin Dohrmann Nynke Raven Aaron Schultz Rodrigo Hamede Anne-Lise Gérard Mathieu Giraudeau Frédéric Thomas Beata Ujvari |
| author_sort | Antoine M. Dujon |
| collection | DOAJ |
| description | Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts. |
| first_indexed | 2024-12-22T00:36:10Z |
| format | Article |
| id | doaj.art-395a8635e1c44a3192502c60fff5d94a |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-22T00:36:10Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-395a8635e1c44a3192502c60fff5d94a2022-12-21T18:44:48ZengElsevieriScience2589-00422020-07-01237101269Transmissible Cancers in an Evolutionary PerspectiveAntoine M. Dujon0Robert A. Gatenby1Georgina Bramwell2Nick MacDonald3Erin Dohrmann4Nynke Raven5Aaron Schultz6Rodrigo Hamede7Anne-Lise Gérard8Mathieu Giraudeau9Frédéric Thomas10Beata Ujvari11Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaDepartment of Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USADeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaDeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaDeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaDeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaDeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, AustraliaSchool of Natural Sciences, University of Tasmania, Private Bag 55, Hobart, TAS 7001, AustraliaCREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, FranceCREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, FranceCREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, FranceDeakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia; School of Natural Sciences, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia; Corresponding authorInter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.http://www.sciencedirect.com/science/article/pii/S2589004220304557Biological SciencesEvolutionary BiologyEvolutionary EcologyCancer |
| spellingShingle | Antoine M. Dujon Robert A. Gatenby Georgina Bramwell Nick MacDonald Erin Dohrmann Nynke Raven Aaron Schultz Rodrigo Hamede Anne-Lise Gérard Mathieu Giraudeau Frédéric Thomas Beata Ujvari Transmissible Cancers in an Evolutionary Perspective iScience Biological Sciences Evolutionary Biology Evolutionary Ecology Cancer |
| title | Transmissible Cancers in an Evolutionary Perspective |
| title_full | Transmissible Cancers in an Evolutionary Perspective |
| title_fullStr | Transmissible Cancers in an Evolutionary Perspective |
| title_full_unstemmed | Transmissible Cancers in an Evolutionary Perspective |
| title_short | Transmissible Cancers in an Evolutionary Perspective |
| title_sort | transmissible cancers in an evolutionary perspective |
| topic | Biological Sciences Evolutionary Biology Evolutionary Ecology Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220304557 |
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