COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication
COL1A1-PDGFB gene fusion associated uterine sarcoma, so called dermatofibrosarcoma-like tumor, a recently reported entity in the uterine corpus, morphologically appears as high grade sarcoma with some features of dermatofibrosarcoma. So far only one other case has been reported in the uterine corpus...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Gynecologic Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578919301122 |
| _version_ | 1811279898398949376 |
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| author | Samuel L. Grindstaff Jessica DiSilvestro Katrine Hansen Paul DiSilvestro C. James Sung M. Ruhul Quddus |
| author_facet | Samuel L. Grindstaff Jessica DiSilvestro Katrine Hansen Paul DiSilvestro C. James Sung M. Ruhul Quddus |
| author_sort | Samuel L. Grindstaff |
| collection | DOAJ |
| description | COL1A1-PDGFB gene fusion associated uterine sarcoma, so called dermatofibrosarcoma-like tumor, a recently reported entity in the uterine corpus, morphologically appears as high grade sarcoma with some features of dermatofibrosarcoma. So far only one other case has been reported in the uterine corpus and two in the uterine cervix. Identification of this gene fusion allows greater choice of targeted therapy in these patients. All the reported cases in the mullerian system are found to be CD34 positive by immunohistochemistry, a commonly used antibody in most immunohistochemistry laboratories. We would, therefore, propose routine CD34 immunohistochemical staining in all high grade uterine sarcomas which have failed other common immunohistochemical markers. Keywords: Uterine sarcoma, Dermatofibrosarcoma protuberans (DFSP), COL1A1-PDGFB fusion, Imatinib |
| first_indexed | 2024-04-13T01:04:08Z |
| format | Article |
| id | doaj.art-395e1e55c9fb43d7839993e372e69d58 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-13T01:04:08Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-395e1e55c9fb43d7839993e372e69d582022-12-22T03:09:24ZengElsevierGynecologic Oncology Reports2352-57892020-02-0131COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implicationSamuel L. Grindstaff0Jessica DiSilvestro1Katrine Hansen2Paul DiSilvestro3C. James Sung4M. Ruhul Quddus5Department of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Corresponding author.Program in Women’s Oncology, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USADepartment of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USAProgram in Women’s Oncology, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USADepartment of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USADepartment of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USACOL1A1-PDGFB gene fusion associated uterine sarcoma, so called dermatofibrosarcoma-like tumor, a recently reported entity in the uterine corpus, morphologically appears as high grade sarcoma with some features of dermatofibrosarcoma. So far only one other case has been reported in the uterine corpus and two in the uterine cervix. Identification of this gene fusion allows greater choice of targeted therapy in these patients. All the reported cases in the mullerian system are found to be CD34 positive by immunohistochemistry, a commonly used antibody in most immunohistochemistry laboratories. We would, therefore, propose routine CD34 immunohistochemical staining in all high grade uterine sarcomas which have failed other common immunohistochemical markers. Keywords: Uterine sarcoma, Dermatofibrosarcoma protuberans (DFSP), COL1A1-PDGFB fusion, Imatinibhttp://www.sciencedirect.com/science/article/pii/S2352578919301122 |
| spellingShingle | Samuel L. Grindstaff Jessica DiSilvestro Katrine Hansen Paul DiSilvestro C. James Sung M. Ruhul Quddus COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication Gynecologic Oncology Reports |
| title | COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication |
| title_full | COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication |
| title_fullStr | COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication |
| title_full_unstemmed | COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication |
| title_short | COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication |
| title_sort | col1a1 pdgfb fusion uterine fibrosarcoma a case report with treatment implication |
| url | http://www.sciencedirect.com/science/article/pii/S2352578919301122 |
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