Topiramate-induced acute angle closure: A systematic review of case reports and case series
Topiramate-induced acute angle closure (TiAAC) is a potentially vision-threatening side effect of topiramate (TPM) use. The purpose of this article is to review demographic characteristics, clinical features, and management options of TiAAC. A systematic literature search of all reported cases and c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1491;epage=1501;aulast=Al |
| _version_ | 1828335941343772672 |
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| author | Adi Mohammed Al Owaifeer Zahra Mohammed AlSultan Abdulrahman H Badawi |
| author_facet | Adi Mohammed Al Owaifeer Zahra Mohammed AlSultan Abdulrahman H Badawi |
| author_sort | Adi Mohammed Al Owaifeer |
| collection | DOAJ |
| description | Topiramate-induced acute angle closure (TiAAC) is a potentially vision-threatening side effect of topiramate (TPM) use. The purpose of this article is to review demographic characteristics, clinical features, and management options of TiAAC. A systematic literature search of all reported cases and case series of TiAAC was conducted in the following search engines: PubMed, Web of Science, Google Scholar, Elsevier, and EBSCO. Seventy-three publications describing 77 cases were included. 58 (75.3%) patients were female, and the mean age was 34.88 ± 11.21 years (range, 7–57). The most commonly reported indication of TPM use was migraine headache (59.7%), and the mean duration from starting treatment until the onset of angle closure was 14.1 ± 31.5 days. All cases were managed by immediate cessation of TPM and topical therapy. In addition, systemic medications (carbonic anhydrase inhibitors, hyperosmotic agents, and steroids) were used in 51 patients (66.2%). A laser and/or surgical intervention was performed in 10 patients (13%). After commencement of treatment, the mean duration until the resolution of TiAAC was 3.9 ± 3.6 days (range, 1–18). The findings of our study present a summary of the current body of evidence provided by case reports and case series on TiAAC. In conclusion, the onset of angle closure following TPM use peaks at 2 weeks after initiating treatment, and in most cases, successful management can be achieved by discontinuing TPM and initiating appropriate medical therapy. |
| first_indexed | 2024-04-13T21:53:35Z |
| format | Article |
| id | doaj.art-395fb9f49e064d99834854511f01af6a |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-13T21:53:35Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-395fb9f49e064d99834854511f01af6a2022-12-22T02:28:21ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017051491150110.4103/ijo.IJO_2134_21Topiramate-induced acute angle closure: A systematic review of case reports and case seriesAdi Mohammed Al OwaifeerZahra Mohammed AlSultanAbdulrahman H BadawiTopiramate-induced acute angle closure (TiAAC) is a potentially vision-threatening side effect of topiramate (TPM) use. The purpose of this article is to review demographic characteristics, clinical features, and management options of TiAAC. A systematic literature search of all reported cases and case series of TiAAC was conducted in the following search engines: PubMed, Web of Science, Google Scholar, Elsevier, and EBSCO. Seventy-three publications describing 77 cases were included. 58 (75.3%) patients were female, and the mean age was 34.88 ± 11.21 years (range, 7–57). The most commonly reported indication of TPM use was migraine headache (59.7%), and the mean duration from starting treatment until the onset of angle closure was 14.1 ± 31.5 days. All cases were managed by immediate cessation of TPM and topical therapy. In addition, systemic medications (carbonic anhydrase inhibitors, hyperosmotic agents, and steroids) were used in 51 patients (66.2%). A laser and/or surgical intervention was performed in 10 patients (13%). After commencement of treatment, the mean duration until the resolution of TiAAC was 3.9 ± 3.6 days (range, 1–18). The findings of our study present a summary of the current body of evidence provided by case reports and case series on TiAAC. In conclusion, the onset of angle closure following TPM use peaks at 2 weeks after initiating treatment, and in most cases, successful management can be achieved by discontinuing TPM and initiating appropriate medical therapy.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1491;epage=1501;aulast=Alangle-closureglaucomatopiramate |
| spellingShingle | Adi Mohammed Al Owaifeer Zahra Mohammed AlSultan Abdulrahman H Badawi Topiramate-induced acute angle closure: A systematic review of case reports and case series Indian Journal of Ophthalmology angle-closure glaucoma topiramate |
| title | Topiramate-induced acute angle closure: A systematic review of case reports and case series |
| title_full | Topiramate-induced acute angle closure: A systematic review of case reports and case series |
| title_fullStr | Topiramate-induced acute angle closure: A systematic review of case reports and case series |
| title_full_unstemmed | Topiramate-induced acute angle closure: A systematic review of case reports and case series |
| title_short | Topiramate-induced acute angle closure: A systematic review of case reports and case series |
| title_sort | topiramate induced acute angle closure a systematic review of case reports and case series |
| topic | angle-closure glaucoma topiramate |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1491;epage=1501;aulast=Al |
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