Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications
The association of smart mobile devices and lab-on-chip technologies offers unprecedented opportunities for the emergence of direct-to-consumer in vitro medical diagnostics applications. Despite their clear transformative potential, obstacles remain to the large-scale disruption and long-lasting suc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-09-01
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| Series: | Diagnostics |
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| Online Access: | http://www.mdpi.com/2075-4418/6/3/33 |
| _version_ | 1811262470988234752 |
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| author | François Patou Fatima AlZahra’a Alatraktchi Claus Kjægaard Maria Dimaki Jan Madsen Winnie E. Svendsen |
| author_facet | François Patou Fatima AlZahra’a Alatraktchi Claus Kjægaard Maria Dimaki Jan Madsen Winnie E. Svendsen |
| author_sort | François Patou |
| collection | DOAJ |
| description | The association of smart mobile devices and lab-on-chip technologies offers unprecedented opportunities for the emergence of direct-to-consumer in vitro medical diagnostics applications. Despite their clear transformative potential, obstacles remain to the large-scale disruption and long-lasting success of these systems in the consumer market. For instance, the increasing level of complexity of instrumented lab-on-chip devices, coupled to the sporadic nature of point-of-care testing, threatens the viability of a business model mainly relying on disposable/consumable lab-on-chips. We argued recently that system evolvability, defined as the design characteristic that facilitates more manageable transitions between system generations via the modification of an inherited design, can help remedy these limitations. In this paper, we discuss how platform-based design can constitute a formal entry point to the design and implementation of evolvable smart device/lab-on-chip systems. We present both a hardware/software design framework and the implementation details of a platform prototype enabling at this stage the interfacing of several lab-on-chip variants relying on current- or impedance-based biosensors. Our findings suggest that several change-enabling mechanisms implemented in the higher abstraction software layers of the system can promote evolvability, together with the design of change-absorbing hardware/software interfaces. Our platform architecture is based on a mobile software application programming interface coupled to a modular hardware accessory. It allows the specification of lab-on-chip operation and post-analytic functions at the mobile software layer. We demonstrate its potential by operating a simple lab-on-chip to carry out the detection of dopamine using various electroanalytical methods. |
| first_indexed | 2024-04-12T19:27:14Z |
| format | Article |
| id | doaj.art-39637d63865b4c939dcc6223d889ff9c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-12T19:27:14Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-39637d63865b4c939dcc6223d889ff9c2022-12-22T03:19:27ZengMDPI AGDiagnostics2075-44182016-09-01633310.3390/diagnostics6030033diagnostics6030033Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics ApplicationsFrançois Patou0Fatima AlZahra’a Alatraktchi1Claus Kjægaard2Maria Dimaki3Jan Madsen4Winnie E. Svendsen5Department of Micro and Nanotechnology, Technical University of Denmark, 2800 Lyngby, DenmarkDepartment of Micro and Nanotechnology, Technical University of Denmark, 2800 Lyngby, DenmarkDepartment of Electrical Engineering, Technical University of Denmark, 2800 Lyngby, DenmarkDepartment of Micro and Nanotechnology, Technical University of Denmark, 2800 Lyngby, DenmarkDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, 2800 Lyngby, DenmarkDepartment of Micro and Nanotechnology, Technical University of Denmark, 2800 Lyngby, DenmarkThe association of smart mobile devices and lab-on-chip technologies offers unprecedented opportunities for the emergence of direct-to-consumer in vitro medical diagnostics applications. Despite their clear transformative potential, obstacles remain to the large-scale disruption and long-lasting success of these systems in the consumer market. For instance, the increasing level of complexity of instrumented lab-on-chip devices, coupled to the sporadic nature of point-of-care testing, threatens the viability of a business model mainly relying on disposable/consumable lab-on-chips. We argued recently that system evolvability, defined as the design characteristic that facilitates more manageable transitions between system generations via the modification of an inherited design, can help remedy these limitations. In this paper, we discuss how platform-based design can constitute a formal entry point to the design and implementation of evolvable smart device/lab-on-chip systems. We present both a hardware/software design framework and the implementation details of a platform prototype enabling at this stage the interfacing of several lab-on-chip variants relying on current- or impedance-based biosensors. Our findings suggest that several change-enabling mechanisms implemented in the higher abstraction software layers of the system can promote evolvability, together with the design of change-absorbing hardware/software interfaces. Our platform architecture is based on a mobile software application programming interface coupled to a modular hardware accessory. It allows the specification of lab-on-chip operation and post-analytic functions at the mobile software layer. We demonstrate its potential by operating a simple lab-on-chip to carry out the detection of dopamine using various electroanalytical methods.http://www.mdpi.com/2075-4418/6/3/33lab-on-chipsmartphonepoint-of-caresystem evolvabilityplatform-based designelectrochemistry |
| spellingShingle | François Patou Fatima AlZahra’a Alatraktchi Claus Kjægaard Maria Dimaki Jan Madsen Winnie E. Svendsen Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications Diagnostics lab-on-chip smartphone point-of-care system evolvability platform-based design electrochemistry |
| title | Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications |
| title_full | Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications |
| title_fullStr | Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications |
| title_full_unstemmed | Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications |
| title_short | Evolvable Smartphone-Based Platforms for Point-of-Care In-Vitro Diagnostics Applications |
| title_sort | evolvable smartphone based platforms for point of care in vitro diagnostics applications |
| topic | lab-on-chip smartphone point-of-care system evolvability platform-based design electrochemistry |
| url | http://www.mdpi.com/2075-4418/6/3/33 |
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