Co‐occurrence of CDKN2A/B and IFN‐I homozygous deletions correlates with an immunosuppressive phenotype and poor prognosis in lung adenocarcinoma

Co‐occurrence of CDKN2A/B and IFN‐I homozygous deletions correlates with an immunosuppressive phenotype and poor prognosis in lung adenocarcinoma

Homozygous deletion (HD) of CDKN2A and CDKN2B (CDKN2A/BHD) is the most frequent copy‐number variation (CNV) in lung adenocarcinoma (LUAD). CDKN2A/BHD has been associated with poor outcomes in LUAD; however, the mechanisms of its prognostic effect remain unknown. We analyzed genome, transcriptome, an...

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Bibliographic Details
Main Authors: Yuan Peng, Yonghong Chen, Mengmeng Song, Xiaoyue Zhang, Pansong Li, Xian Yu, Yusheng Huang, Ni Zhang, Liyan Ji, Lei Xia, Xuefeng Xia, Xin Yi, Benxu Tan, Zhenzhou Yang
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Molecular Oncology
Subjects:
CDKN2A/B
homozygous deletion
tumor immune microenvironment
type I interferons
Online Access:https://doi.org/10.1002/1878-0261.13206

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