<i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals
Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity...
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2023-02-01
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author | Yulia A. Kondratenko Julia S. Shilova Vladislav A. Gavrilov Andrey A. Zolotarev Michail A. Nadporojskii Tatyana A. Kochina Dmitrii O. Antuganov |
author_facet | Yulia A. Kondratenko Julia S. Shilova Vladislav A. Gavrilov Andrey A. Zolotarev Michail A. Nadporojskii Tatyana A. Kochina Dmitrii O. Antuganov |
author_sort | Yulia A. Kondratenko |
collection | DOAJ |
description | Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing <i>N</i>-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (<sup>1</sup>H, <sup>13</sup>C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in <sup>68</sup>Ga- and Al<sup>18</sup>F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-labeled radiopharmaceuticals. |
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issn | 1999-4923 |
language | English |
last_indexed | 2024-03-11T08:15:39Z |
publishDate | 2023-02-01 |
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spelling | doaj.art-3965fd5dd6b846e58e1edd316a428fdc2023-11-16T22:43:22ZengMDPI AGPharmaceutics1999-49232023-02-0115269410.3390/pharmaceutics15020694<i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled RadiopharmaceuticalsYulia A. Kondratenko0Julia S. Shilova1Vladislav A. Gavrilov2Andrey A. Zolotarev3Michail A. Nadporojskii4Tatyana A. Kochina5Dmitrii O. Antuganov6Grebenshchikov Institute of Silicate Chemistry RAS, Nab. Makarova, 2, 199034 Saint-Petersburg, RussiaSt. Petersburg State Technological Institute, Technical University, 26 Moskovsky Pr., 190013 Saint-Petersburg, RussiaSt. Petersburg State Technological Institute, Technical University, 26 Moskovsky Pr., 190013 Saint-Petersburg, RussiaInstitute of Earth Sciences, St. Petersburg State University, University Emb. 7/9, 199034 Saint-Petersburg, RussiaGranov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Str. 70, Pesochny, 197758 Saint-Petersburg, RussiaGrebenshchikov Institute of Silicate Chemistry RAS, Nab. Makarova, 2, 199034 Saint-Petersburg, RussiaGranov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Str. 70, Pesochny, 197758 Saint-Petersburg, RussiaIonic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing <i>N</i>-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (<sup>1</sup>H, <sup>13</sup>C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in <sup>68</sup>Ga- and Al<sup>18</sup>F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-labeled radiopharmaceuticals.https://www.mdpi.com/1999-4923/15/2/694Good’s buffer ionic liquids<i>N</i>-benzylethanolaminealkanolammonium saltsradiopharmaceuticalsnuclear medicinePET |
spellingShingle | Yulia A. Kondratenko Julia S. Shilova Vladislav A. Gavrilov Andrey A. Zolotarev Michail A. Nadporojskii Tatyana A. Kochina Dmitrii O. Antuganov <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals Pharmaceutics Good’s buffer ionic liquids <i>N</i>-benzylethanolamine alkanolammonium salts radiopharmaceuticals nuclear medicine PET |
title | <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals |
title_full | <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals |
title_fullStr | <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals |
title_full_unstemmed | <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals |
title_short | <i>N</i>-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of <sup>68</sup>Ga- and Al<sup>18</sup>F-Labeled Radiopharmaceuticals |
title_sort | i n i benzylethanolammonium ionic liquids and molten salts in the synthesis of sup 68 sup ga and al sup 18 sup f labeled radiopharmaceuticals |
topic | Good’s buffer ionic liquids <i>N</i>-benzylethanolamine alkanolammonium salts radiopharmaceuticals nuclear medicine PET |
url | https://www.mdpi.com/1999-4923/15/2/694 |
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