Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide

Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide

Abstract Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modulate TMZ sensitivity via regulation of SORBS2 and DDR...

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Bibliographic Details
Main Authors: Tengfei Shi, Dianhao Guo, Yaoqiang Zheng, Wenbin Wang, Jinfang Bi, Anshun He, Sibo Fan, Guangsong Su, Xueyuan Zhao, Zhenhao Zhao, Yingjie Song, Shupeng Sun, Peng Li, Zhongfang Zhao, Jiandang Shi, Wange Lu, Lei Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06392-w

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