Structural basis for subtype-specific inhibition of the P2X7 receptor

Structural basis for subtype-specific inhibition of the P2X7 receptor

The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine triphosphate (ATP). Chronic activation of P2X7 underlies many health problems such as pathologic pain, yet we lack effective antagonists due to poorly understood mechanisms of inhibition. Here we present crystal...

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Bibliographic Details
Main Authors: Akira Karasawa, Toshimitsu Kawate
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
P2X7 receptor
allosteric inhibition
X-ray structure
ATP-gated ion channels
Online Access:https://elifesciences.org/articles/22153

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