COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome
Abstract To investigate the effect of COVID-19 infection or vaccine on IVF outcome. This is a multicenter retrospective study. Data were collected from all patients treated in the ART units between September and November 2021 after the vaccination of the general population began. Medical records of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25757-3 |
| _version_ | 1811196692278542336 |
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| author | Soha Albeitawi Zina M. Al-Alami Jehan Hamadneh Hiba Alqam Hussein Qublan Maha Al Natsheh |
| author_facet | Soha Albeitawi Zina M. Al-Alami Jehan Hamadneh Hiba Alqam Hussein Qublan Maha Al Natsheh |
| author_sort | Soha Albeitawi |
| collection | DOAJ |
| description | Abstract To investigate the effect of COVID-19 infection or vaccine on IVF outcome. This is a multicenter retrospective study. Data were collected from all patients treated in the ART units between September and November 2021 after the vaccination of the general population began. Medical records of all patients who had IVF/intracytoplasmic sperm injection (ICSI) were retrospectively reviewed. Patients were categorized into four groups: previously infected by COVID-19, vaccinated by COVID vaccine, previously infected and vaccinated, or neither infected nor vaccinated. Total number of participants 151 (vaccinated only 66, infected only 18, vaccinated and previously infected 34, and control 33. Outcomes (ET on day of trigger, number of oocytes retrieved, quality of oocytes, number of fertilized oocytes, number and quality of embryos, number of embryos transferred, number of embryos frozen, implantation rate and clinical pregnancy rate) were compared between these four groups. Moreover, we compared the outcome before and post infection, as well as before and post vaccine in a group of patients. No evidence was found to suggest that COVID-19 disease or SARS-CoV-2 Vaccine adversely affects Clinical pregnancy rates (positive fetal heartbeat) (OR 0.9, CI 0.5–1.9, OR 1.8, CI 0.9–3.6, respectively) and the following parameters: fertilization rate, implantation rate, positive bHcg) (OR 0.9, CI 0.5–1.8, OR 1.5, CI 0.7–2.9, respectively). Although a limitation of our study is the small comparison groups, and the wide confidence intervals in the Odds Ratio estimates. |
| first_indexed | 2024-04-12T01:03:15Z |
| format | Article |
| id | doaj.art-396a524ed2b442c089f3922039c9b598 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T01:03:15Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-396a524ed2b442c089f3922039c9b5982022-12-22T03:54:23ZengNature PortfolioScientific Reports2045-23222022-12-011211810.1038/s41598-022-25757-3COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcomeSoha Albeitawi0Zina M. Al-Alami1Jehan Hamadneh2Hiba Alqam3Hussein Qublan4Maha Al Natsheh5Clinical Science Department, Faculty of Medicine, Yarmouk UniversityFaculty of Allied Medical Sciences, Al-Ahliyya Amman UniversityObstetrics and Gynecology Department, Jordan University of Science and TechnologyClinical Science Department, Faculty of Medicine, Yarmouk UniversityIrbid Specialty Hospital IVF Center, Irbid Specialty HospitalAl Kindi IVF Unit, Al Kindi HospitalAbstract To investigate the effect of COVID-19 infection or vaccine on IVF outcome. This is a multicenter retrospective study. Data were collected from all patients treated in the ART units between September and November 2021 after the vaccination of the general population began. Medical records of all patients who had IVF/intracytoplasmic sperm injection (ICSI) were retrospectively reviewed. Patients were categorized into four groups: previously infected by COVID-19, vaccinated by COVID vaccine, previously infected and vaccinated, or neither infected nor vaccinated. Total number of participants 151 (vaccinated only 66, infected only 18, vaccinated and previously infected 34, and control 33. Outcomes (ET on day of trigger, number of oocytes retrieved, quality of oocytes, number of fertilized oocytes, number and quality of embryos, number of embryos transferred, number of embryos frozen, implantation rate and clinical pregnancy rate) were compared between these four groups. Moreover, we compared the outcome before and post infection, as well as before and post vaccine in a group of patients. No evidence was found to suggest that COVID-19 disease or SARS-CoV-2 Vaccine adversely affects Clinical pregnancy rates (positive fetal heartbeat) (OR 0.9, CI 0.5–1.9, OR 1.8, CI 0.9–3.6, respectively) and the following parameters: fertilization rate, implantation rate, positive bHcg) (OR 0.9, CI 0.5–1.8, OR 1.5, CI 0.7–2.9, respectively). Although a limitation of our study is the small comparison groups, and the wide confidence intervals in the Odds Ratio estimates.https://doi.org/10.1038/s41598-022-25757-3 |
| spellingShingle | Soha Albeitawi Zina M. Al-Alami Jehan Hamadneh Hiba Alqam Hussein Qublan Maha Al Natsheh COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome Scientific Reports |
| title | COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome |
| title_full | COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome |
| title_fullStr | COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome |
| title_full_unstemmed | COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome |
| title_short | COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome |
| title_sort | covid 19 infection and vaccine have no impact on in vitro fertilization ivf outcome |
| url | https://doi.org/10.1038/s41598-022-25757-3 |
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