Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?
Recent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases. In this review, we will explore a key common pathological mechanism, i.e., the loss of neuroprotective factors, across the three major neurodege...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00672/full |
| _version_ | 1818615868011053056 |
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| author | Luisa Benussi Giuliano Binetti Giuliano Binetti Roberta Ghidoni |
| author_facet | Luisa Benussi Giuliano Binetti Giuliano Binetti Roberta Ghidoni |
| author_sort | Luisa Benussi |
| collection | DOAJ |
| description | Recent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases. In this review, we will explore a key common pathological mechanism, i.e., the loss of neuroprotective factors, across the three major neurodegenerative diseases leading to dementia: Alzheimer's disease (AD), Frontotemporal dementia (FTD) and Lewy body dementia (LBD). We will report evidences that the Brain Derived Neurotrophic Factor (BDNF), the most investigated and characterized brain neurotrophin, progranulin, a multi-functional adipokine with trophic and growth factor properties, and cystatin C, a neuroprotective growth factor, are reduced in AD, FTD, and LBD. Moreover, we will review the molecular mechanism underlying the loss of neuroprotective factors in neurodegenerative diseases leading to dementia, with a special focus on endo-lysosomal pathway and intercellular communication mediated by extracellular vesicles. Exploring the shared commonality of disease mechanisms is of pivotal importance to identify novel potential therapeutic targets and to develop treatments to delay, slow or block disease progression. |
| first_indexed | 2024-12-16T16:40:44Z |
| format | Article |
| id | doaj.art-396b91dbf6e74233931c119f040d860e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T16:40:44Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-396b91dbf6e74233931c119f040d860e2022-12-21T22:24:20ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-12-011110.3389/fnins.2017.00672312759Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?Luisa Benussi0Giuliano Binetti1Giuliano Binetti2Roberta Ghidoni3Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyMAC Memory Center, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyRecent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases. In this review, we will explore a key common pathological mechanism, i.e., the loss of neuroprotective factors, across the three major neurodegenerative diseases leading to dementia: Alzheimer's disease (AD), Frontotemporal dementia (FTD) and Lewy body dementia (LBD). We will report evidences that the Brain Derived Neurotrophic Factor (BDNF), the most investigated and characterized brain neurotrophin, progranulin, a multi-functional adipokine with trophic and growth factor properties, and cystatin C, a neuroprotective growth factor, are reduced in AD, FTD, and LBD. Moreover, we will review the molecular mechanism underlying the loss of neuroprotective factors in neurodegenerative diseases leading to dementia, with a special focus on endo-lysosomal pathway and intercellular communication mediated by extracellular vesicles. Exploring the shared commonality of disease mechanisms is of pivotal importance to identify novel potential therapeutic targets and to develop treatments to delay, slow or block disease progression.http://journal.frontiersin.org/article/10.3389/fnins.2017.00672/fullBDNFprogranulincystatin Cbiomarkersfrontotemporal dementiaAlzheimer's disease |
| spellingShingle | Luisa Benussi Giuliano Binetti Giuliano Binetti Roberta Ghidoni Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? Frontiers in Neuroscience BDNF progranulin cystatin C biomarkers frontotemporal dementia Alzheimer's disease |
| title | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| title_full | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| title_fullStr | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| title_full_unstemmed | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| title_short | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| title_sort | loss of neuroprotective factors in neurodegenerative dementias the end or the starting point |
| topic | BDNF progranulin cystatin C biomarkers frontotemporal dementia Alzheimer's disease |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00672/full |
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