Endovascular radiofrequency renal denervation in resistant hypertension: a single center experience
Eight patients with office blood pressure >140/90 mmHg, despite being treated with at least three antihypertensive drugs, underwent catheter-based renal denervation. Secondary hypertension was excluded in all patients. Every patient underwent follow-up at 30 days, and then every 3 months. At...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2013-11-01
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| Series: | Italian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.italjmed.org/index.php/ijm/article/view/174 |
| Summary: | Eight patients with office blood pressure >140/90 mmHg, despite being treated with at least three antihypertensive drugs, underwent catheter-based renal denervation. Secondary hypertension was excluded in all patients. Every patient underwent follow-up at 30 days, and then every 3 months. At 6 and 12 months the median value of systolic clinic blood pressure decreased from 161 mmHg (25<sup>th</sup>-75<sup>th</sup> percentiles: 158-191 mmHg) at baseline to 144 mmHg (25<sup>th</sup>-75<sup>th</sup> percentiles: 136-153 mmHg) at follow up (P=0.012), and the median value of diastolic clinic blood pressure decreased from 102 mmHg (25<sup>th</sup>-75<sup>th</sup> percentiles: 94-122 mmHg) at baseline to 90 mmHg (25<sup>th</sup>-75<sup>th</sup> percentiles: 78-99 mmHg) at follow-up (P=0.012). The number of medications decreased from 5 (range, 2-8) at baseline to 3.3 (range, 0-6) at follow up. There was a significant decrease of left ventricular mass index from a median of 160 g/m<sup>2</sup> (25<sup>th</sup>-75<sup>th</sup> percentiles: 147-151 g/m<sup>2</sup>) at baseline to 126 g/m<sup>2</sup> (25<sup>th</sup>-75<sup>th</sup> percentiles 107-151 g/m<sup>2</sup>) at follow-up (P=0.043) was detected. The renal function, and metabolic and neurohumoral parameters, did not change significantly. No complications were observed. |
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| ISSN: | 1877-9344 1877-9352 |