Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury

Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury

Abstract Background NLRP3 inflammasome activation and pyroptosis play a significant role in myocardial ischemia reperfusion injury (MI/RI). Geniposide was reported to show potential therapeutic use for MI/RI with its anti-inflammatory and anti-oxidative properties. However, research on the specific...

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Bibliographic Details
Main Authors: Haiyan Li, Dong-Hua Yang, Yanmei Zhang, Fuchun Zheng, Fenfei Gao, Jiajia Sun, Ganggang Shi
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Chinese Medicine
Subjects:
Myocardial ischemia reperfusion
Geniposide
AMPK
NLRP3 inflammasome
Pyroptosis
Online Access:https://doi.org/10.1186/s13020-022-00616-5

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