CCR9 initiates epithelial–mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis

CCR9 initiates epithelial–mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis

Abstract Background Osteosarcoma (OS) patients with lung metastasis have poor prognoses, and effective therapeutic strategies for delaying or inhibiting the spread of lung metastasis from the primary OS site are lacking. Hence, it is critical to elucidate the underlying mechanisms of OS metastasis a...

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Bibliographic Details
Main Authors: Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu, Huiyong Shen
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Cancer Cell International
Subjects:
CCR9
Lung metastasis
Osteosarcoma
Epithelial–mesenchymal transition
Wnt/β-catenin
Online Access:https://doi.org/10.1186/s12935-021-02320-0

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