A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia

A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia

Abstract The hypoxic microenvironment is presumed to be a sanctuary for myeloid leukemia cells that causes relapse following chemotherapy, but the underlying mechanism remains elusive. Using a zebrafish xenograft model, we observed that the hypoxic hematopoietic tissue preserved most of the chemores...

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Bibliographic Details
Main Authors: Yunxin Zeng, Xinyu Zhang, Dongjun Lin, Xiaohui Feng, Yuye Liu, Zhengwen Fang, Weijian Zhang, Yu Chen, Meng Zhao, Jun Wu, Linjia Jiang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Hematology & Oncology
Subjects:
Myeloid leukemia
Chemotherapy
Doxorubicin
Hypoxia
Lysosome
Online Access:https://doi.org/10.1186/s13045-021-01199-8

Internet

https://doi.org/10.1186/s13045-021-01199-8

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