Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period
Abstract Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of both SCLC...
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| Format: | Article |
| Language: | English |
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BMC
2016-07-01
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| Series: | Chinese Journal of Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40880-016-0127-x |
| _version_ | 1819154589548544000 |
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| author | Fumio Asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe Hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko |
| author_facet | Fumio Asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe Hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko |
| author_sort | Fumio Asano |
| collection | DOAJ |
| description | Abstract Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period. |
| first_indexed | 2024-12-22T15:23:29Z |
| format | Article |
| id | doaj.art-3971293db85f4ff59f068dff9a4500b8 |
| institution | Directory Open Access Journal |
| issn | 1944-446X |
| language | English |
| last_indexed | 2024-12-22T15:23:29Z |
| publishDate | 2016-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Journal of Cancer |
| spelling | doaj.art-3971293db85f4ff59f068dff9a4500b82022-12-21T18:21:33ZengBMCChinese Journal of Cancer1944-446X2016-07-013511510.1186/s40880-016-0127-xRelapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival periodFumio Asano0Keisuke Watanabe1Masaharu Shinkai2Yoshitaka Tei3Kei Mishina4Mikiko Tanabe5Hiroshi Ishii6Masahiro Shinoda7Tadasuke Shimokawaji8Makoto Kudo9Takeshi Kaneko10Respiratory Disease Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterDepartment of Pathology, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterComprehensive Cancer Center, Yokohama City University Medical CenterRespiratory Disease Center, Yokohama City University Medical CenterDepartment of Pulmonology, Yokohama City University Graduate School of MedicineAbstract Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.http://link.springer.com/article/10.1186/s40880-016-0127-xLambert–Eaton myasthenic syndromeParaneoplastic syndromeParaneoplastic neurological syndromeP/Q-type anti-voltage-gated calcium channel antibodySmall cell lung carcinoma |
| spellingShingle | Fumio Asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe Hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period Chinese Journal of Cancer Lambert–Eaton myasthenic syndrome Paraneoplastic syndrome Paraneoplastic neurological syndrome P/Q-type anti-voltage-gated calcium channel antibody Small cell lung carcinoma |
| title | Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period |
| title_full | Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period |
| title_fullStr | Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period |
| title_full_unstemmed | Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period |
| title_short | Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period |
| title_sort | relapse of both small cell lung cancer and lambert eaton myasthenic syndrome after a 13 year disease free survival period |
| topic | Lambert–Eaton myasthenic syndrome Paraneoplastic syndrome Paraneoplastic neurological syndrome P/Q-type anti-voltage-gated calcium channel antibody Small cell lung carcinoma |
| url | http://link.springer.com/article/10.1186/s40880-016-0127-x |
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