Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect
Abstract Cranberry is associated with multiple health benefits, which are mostly attributed to its high content of (poly)phenols, particularly flavan-3-ols. However, clinical trials attempting to demonstrate these positive effects have yielded heterogeneous results, partly due to the high inter-indi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00493-w |
| _version_ | 1797266895292858368 |
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| author | Jacob Lessard-Lord Charlène Roussel Joseph Lupien-Meilleur Pamela Généreux Véronique Richard Valérie Guay Denis Roy Yves Desjardins |
| author_facet | Jacob Lessard-Lord Charlène Roussel Joseph Lupien-Meilleur Pamela Généreux Véronique Richard Valérie Guay Denis Roy Yves Desjardins |
| author_sort | Jacob Lessard-Lord |
| collection | DOAJ |
| description | Abstract Cranberry is associated with multiple health benefits, which are mostly attributed to its high content of (poly)phenols, particularly flavan-3-ols. However, clinical trials attempting to demonstrate these positive effects have yielded heterogeneous results, partly due to the high inter-individual variability associated with gut microbiota interaction with these molecules. In fact, several studies have demonstrated the ability of these molecules to modulate the gut microbiota in animal and in vitro models, but there is a scarcity of information in human subjects. In addition, it has been recently reported that cranberry also contains high concentrations of oligosaccharides, which could contribute to its bioactivity. Hence, the aim of this study was to fully characterize the (poly)phenolic and oligosaccharidic contents of a commercially available cranberry extract and evaluate its capacity to positively modulate the gut microbiota of 28 human subjects. After only four days, the (poly)phenols and oligosaccharides-rich cranberry extract, induced a strong bifidogenic effect, along with an increase in the abundance of several butyrate-producing bacteria, such as Clostridium and Anaerobutyricum. Plasmatic and fecal short-chain fatty acids profiles were also altered by the cranberry extract with a decrease in acetate ratio and an increase in butyrate ratio. Finally, to characterize the inter-individual variability, we stratified the participants according to the alterations observed in the fecal microbiota following supplementation. Interestingly, individuals having a microbiota characterized by the presence of Prevotella benefited from an increase in Faecalibacterium with the cranberry extract supplementation. |
| first_indexed | 2024-04-25T01:07:57Z |
| format | Article |
| id | doaj.art-397677869d7e4f8cb2d64ee72cd41e7c |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-04-25T01:07:57Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-397677869d7e4f8cb2d64ee72cd41e7c2024-03-10T12:07:09ZengNature Portfolionpj Biofilms and Microbiomes2055-50082024-03-0110111510.1038/s41522-024-00493-wShort term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effectJacob Lessard-Lord0Charlène Roussel1Joseph Lupien-Meilleur2Pamela Généreux3Véronique Richard4Valérie Guay5Denis Roy6Yves Desjardins7Institute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval UniversityAbstract Cranberry is associated with multiple health benefits, which are mostly attributed to its high content of (poly)phenols, particularly flavan-3-ols. However, clinical trials attempting to demonstrate these positive effects have yielded heterogeneous results, partly due to the high inter-individual variability associated with gut microbiota interaction with these molecules. In fact, several studies have demonstrated the ability of these molecules to modulate the gut microbiota in animal and in vitro models, but there is a scarcity of information in human subjects. In addition, it has been recently reported that cranberry also contains high concentrations of oligosaccharides, which could contribute to its bioactivity. Hence, the aim of this study was to fully characterize the (poly)phenolic and oligosaccharidic contents of a commercially available cranberry extract and evaluate its capacity to positively modulate the gut microbiota of 28 human subjects. After only four days, the (poly)phenols and oligosaccharides-rich cranberry extract, induced a strong bifidogenic effect, along with an increase in the abundance of several butyrate-producing bacteria, such as Clostridium and Anaerobutyricum. Plasmatic and fecal short-chain fatty acids profiles were also altered by the cranberry extract with a decrease in acetate ratio and an increase in butyrate ratio. Finally, to characterize the inter-individual variability, we stratified the participants according to the alterations observed in the fecal microbiota following supplementation. Interestingly, individuals having a microbiota characterized by the presence of Prevotella benefited from an increase in Faecalibacterium with the cranberry extract supplementation.https://doi.org/10.1038/s41522-024-00493-w |
| spellingShingle | Jacob Lessard-Lord Charlène Roussel Joseph Lupien-Meilleur Pamela Généreux Véronique Richard Valérie Guay Denis Roy Yves Desjardins Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect npj Biofilms and Microbiomes |
| title | Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| title_full | Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| title_fullStr | Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| title_full_unstemmed | Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| title_short | Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| title_sort | short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect |
| url | https://doi.org/10.1038/s41522-024-00493-w |
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