Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers. Many cancers express reduced levels of these amino acids and thus require import from t...

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Bibliographic Details
Main Authors: Macus Tien Kuo, Helen H. W. Chen, Lynn G. Feun, Niramol Savaraj
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
amino acid starvation therapy
proline
glutamine
arginine
asparagine
drug resistance
Online Access:https://www.mdpi.com/1424-8247/14/1/72

Internet

https://www.mdpi.com/1424-8247/14/1/72

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