The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications
Conjugated polymer nanoparticles (CPNs) are a promising class of nanomaterials for biomedical applications, such as bioimaging, gene and drug delivery/release, photodynamic therapy (PDT), photothermal therapy (PTT), and environmental sensing. Over the past decade, many reports have been published de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/9/1543 |
| _version_ | 1797601988391731200 |
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| author | Miao Zhao Anton Uzunoff Mark Green Aliaksandra Rakovich |
| author_facet | Miao Zhao Anton Uzunoff Mark Green Aliaksandra Rakovich |
| author_sort | Miao Zhao |
| collection | DOAJ |
| description | Conjugated polymer nanoparticles (CPNs) are a promising class of nanomaterials for biomedical applications, such as bioimaging, gene and drug delivery/release, photodynamic therapy (PDT), photothermal therapy (PTT), and environmental sensing. Over the past decade, many reports have been published detailing their synthesis and their various potential applications, including some very comprehensive reviews of these topics. In contrast, there is a distinct lack of overview of the role the stabilizing copolymer shells have on the properties of CPNs. This review attempts to correct this oversight by scrutinizing reports detailing the synthesis and application of CPNs stabilized with some commonly-used copolymers, namely F127 (Pluronic poly(ethylene glycol)-<i>block</i>-poly(propylene glycol)-<i>block</i>-poly(ethylene glycol) diacrylate), PSMA (poly(styrene-co-maleic anhydride)), PLGA (poly(D, L-lactide-co-glycolide)) and PEG (polyethylene glycol) derivatives. The analysis of the reported physicochemical properties and biological applications of these CPNs provides insights into the advantages of each group of copolymers for specific applications and offers a set of guidance criteria for the selection of an appropriate copolymer when designing CPNs-based probes. Finally, the challenges and outlooks in the field are highlighted. |
| first_indexed | 2024-03-11T04:10:53Z |
| format | Article |
| id | doaj.art-397bb02fcd7e4fd78b75ec9c509696d2 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T04:10:53Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-397bb02fcd7e4fd78b75ec9c509696d22023-11-17T23:27:29ZengMDPI AGNanomaterials2079-49912023-05-01139154310.3390/nano13091543The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical ApplicationsMiao Zhao0Anton Uzunoff1Mark Green2Aliaksandra Rakovich3Physics Department, King’s College London, London WC2R 2LS, UKPhysics Department, King’s College London, London WC2R 2LS, UKPhysics Department, King’s College London, London WC2R 2LS, UKPhysics Department, King’s College London, London WC2R 2LS, UKConjugated polymer nanoparticles (CPNs) are a promising class of nanomaterials for biomedical applications, such as bioimaging, gene and drug delivery/release, photodynamic therapy (PDT), photothermal therapy (PTT), and environmental sensing. Over the past decade, many reports have been published detailing their synthesis and their various potential applications, including some very comprehensive reviews of these topics. In contrast, there is a distinct lack of overview of the role the stabilizing copolymer shells have on the properties of CPNs. This review attempts to correct this oversight by scrutinizing reports detailing the synthesis and application of CPNs stabilized with some commonly-used copolymers, namely F127 (Pluronic poly(ethylene glycol)-<i>block</i>-poly(propylene glycol)-<i>block</i>-poly(ethylene glycol) diacrylate), PSMA (poly(styrene-co-maleic anhydride)), PLGA (poly(D, L-lactide-co-glycolide)) and PEG (polyethylene glycol) derivatives. The analysis of the reported physicochemical properties and biological applications of these CPNs provides insights into the advantages of each group of copolymers for specific applications and offers a set of guidance criteria for the selection of an appropriate copolymer when designing CPNs-based probes. Finally, the challenges and outlooks in the field are highlighted.https://www.mdpi.com/2079-4991/13/9/1543conjugated polymer nanoparticlescopolymerstabilizing shellphysicochemical propertiesnanomedicine |
| spellingShingle | Miao Zhao Anton Uzunoff Mark Green Aliaksandra Rakovich The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications Nanomaterials conjugated polymer nanoparticles copolymer stabilizing shell physicochemical properties nanomedicine |
| title | The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications |
| title_full | The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications |
| title_fullStr | The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications |
| title_full_unstemmed | The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications |
| title_short | The Role of Stabilizing Copolymer in Determining the Physicochemical Properties of Conjugated Polymer Nanoparticles and Their Nanomedical Applications |
| title_sort | role of stabilizing copolymer in determining the physicochemical properties of conjugated polymer nanoparticles and their nanomedical applications |
| topic | conjugated polymer nanoparticles copolymer stabilizing shell physicochemical properties nanomedicine |
| url | https://www.mdpi.com/2079-4991/13/9/1543 |
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