Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem
In the gastrointestinal tract (GIT), the immune system interacts with a variety of microorganisms, including pathogens as well as beneficial symbionts that perform important physiological functions for the host and are crucial to sustain intestinal homeostasis. In normal conditions, secretory immuno...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.880484/full |
| _version_ | 1828331775326158848 |
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| author | E. Daniel León M. Pilar Francino M. Pilar Francino |
| author_facet | E. Daniel León M. Pilar Francino M. Pilar Francino |
| author_sort | E. Daniel León |
| collection | DOAJ |
| description | In the gastrointestinal tract (GIT), the immune system interacts with a variety of microorganisms, including pathogens as well as beneficial symbionts that perform important physiological functions for the host and are crucial to sustain intestinal homeostasis. In normal conditions, secretory immunoglobulin A (SIgA) is the principal antibody produced by B cells in the GIT mucosa. Polyreactivity provides certain SIgA molecules with the ability of binding different antigens in the bacterial surface, such as O-antigens and teichoic acids, while cross-species reactivity allows them to recognize and interact with different types of bacteria. These functions may be crucial in allowing SIgA to modulate the complex gut microbiota in an efficient manner. Several studies suggest that SIgA can help with the retention and proliferation of helpful members of the gut microbiota. Gut microbiota alterations in people with IgA deficiency include the lack of some species that are known to be normally coated by SIgA. Here, we discuss the different ways in which SIgA behaves in relation to pathogens and beneficial bacteria of the gut microbiota and how the immune system might protect and facilitate the establishment and maintenance of certain gut symbionts. |
| first_indexed | 2024-04-13T20:56:56Z |
| format | Article |
| id | doaj.art-397dca94f5d445f3b9bd99779b25cbcc |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T20:56:56Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-397dca94f5d445f3b9bd99779b25cbcc2022-12-22T02:30:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.880484880484Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut EcosystemE. Daniel León0M. Pilar Francino1M. Pilar Francino2Department of Genomics and Health, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, SpainDepartment of Genomics and Health, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, SpainCIBER en Epidemiología y Salud Pública, Madrid, SpainIn the gastrointestinal tract (GIT), the immune system interacts with a variety of microorganisms, including pathogens as well as beneficial symbionts that perform important physiological functions for the host and are crucial to sustain intestinal homeostasis. In normal conditions, secretory immunoglobulin A (SIgA) is the principal antibody produced by B cells in the GIT mucosa. Polyreactivity provides certain SIgA molecules with the ability of binding different antigens in the bacterial surface, such as O-antigens and teichoic acids, while cross-species reactivity allows them to recognize and interact with different types of bacteria. These functions may be crucial in allowing SIgA to modulate the complex gut microbiota in an efficient manner. Several studies suggest that SIgA can help with the retention and proliferation of helpful members of the gut microbiota. Gut microbiota alterations in people with IgA deficiency include the lack of some species that are known to be normally coated by SIgA. Here, we discuss the different ways in which SIgA behaves in relation to pathogens and beneficial bacteria of the gut microbiota and how the immune system might protect and facilitate the establishment and maintenance of certain gut symbionts.https://www.frontiersin.org/articles/10.3389/fmicb.2022.880484/fullgut microbiotamicrobiomesecretory IgAimmune systemcross-species reactivity |
| spellingShingle | E. Daniel León M. Pilar Francino M. Pilar Francino Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem Frontiers in Microbiology gut microbiota microbiome secretory IgA immune system cross-species reactivity |
| title | Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem |
| title_full | Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem |
| title_fullStr | Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem |
| title_full_unstemmed | Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem |
| title_short | Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem |
| title_sort | roles of secretory immunoglobulin a in host microbiota interactions in the gut ecosystem |
| topic | gut microbiota microbiome secretory IgA immune system cross-species reactivity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.880484/full |
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