Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study
Abstract Background C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some ca...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-0874-9 |
| _version_ | 1818765973761556480 |
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| author | Takahiro Kanai Yuko Akioka Kenichiro Miura Masataka Hisano Junki Koike Yutaka Yamaguchi Motoshi Hattori |
| author_facet | Takahiro Kanai Yuko Akioka Kenichiro Miura Masataka Hisano Junki Koike Yutaka Yamaguchi Motoshi Hattori |
| author_sort | Takahiro Kanai |
| collection | DOAJ |
| description | Abstract Background C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some cases with normal urinalysis. To confirm the existence of cases with predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick test) and/or hematuria. Methods Eligible participants were kidney transplant cases who corresponded to the criteria for C1qN and were followed more than 10 years. Their medical records were reviewed to determine the age at detection of predominant mesangial C1q deposits, gender, original renal disease and reason for renal graft biopsy, blood pressure, degree of proteinuria and hematuria, and serum creatinine levels. Results From 414 cases in adults and children, five pediatric patients (the male to female ratio, 1:1.5) were eligible. At the time when predominant mesangial C1q deposits were detected, 2 cases presented with mild proteinuria without hematuria, but the other 3 cases showed normal urinalysis. Light microscopy revealed minor glomerular abnormality in all the cases. Immunofluorescent study showed predominant mesangial C1q deposits with IgG, IgM and C3 in all cases. All selected specimens presented electron dense-depos in the mesangium. Ten years later from the detection, 2 cases continued to be normal urinalysis and 3 cases had mild proteinuria without hematuria. During this follow-up period, no cases presented with persistent proteinuria and/or hematuria greater than or equal to 2+ by dip stick test. And no cases developed systemic lupus erythematosus. Follow-up renal graft biopsies were performed once in 2 cases 8 years later from the detection. They showed minor glomerular abnormalities. C1q deposit disappeared in one case. In another case, immunofluorescent study was not examined. Conclusions This long-term observational study on transplanted kidneys confirms the existence of cases with predominant but silent C1q deposits in the mesangium who have negative or mild proteinuria. |
| first_indexed | 2024-12-18T08:26:36Z |
| format | Article |
| id | doaj.art-397ec8e50723425c9efaa6ade968f72f |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-18T08:26:36Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-397ec8e50723425c9efaa6ade968f72f2022-12-21T21:14:35ZengBMCBMC Nephrology1471-23692018-04-011911510.1186/s12882-018-0874-9Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational studyTakahiro Kanai0Yuko Akioka1Kenichiro Miura2Masataka Hisano3Junki Koike4Yutaka Yamaguchi5Motoshi Hattori6Department of Pediatric Nephrology, Kidney Center, Tokyo Women’s Medical UniversityDepartment of Pediatric Nephrology, Kidney Center, Tokyo Women’s Medical UniversityDepartment of Pediatric Nephrology, Kidney Center, Tokyo Women’s Medical UniversityDepartment of Pediatric Nephrology, Kidney Center, Tokyo Women’s Medical UniversityDepartment of Pathology, Kawasaki City Tama HospitalYamaguchi’s Pathology LaboratoryDepartment of Pediatric Nephrology, Kidney Center, Tokyo Women’s Medical UniversityAbstract Background C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some cases with normal urinalysis. To confirm the existence of cases with predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick test) and/or hematuria. Methods Eligible participants were kidney transplant cases who corresponded to the criteria for C1qN and were followed more than 10 years. Their medical records were reviewed to determine the age at detection of predominant mesangial C1q deposits, gender, original renal disease and reason for renal graft biopsy, blood pressure, degree of proteinuria and hematuria, and serum creatinine levels. Results From 414 cases in adults and children, five pediatric patients (the male to female ratio, 1:1.5) were eligible. At the time when predominant mesangial C1q deposits were detected, 2 cases presented with mild proteinuria without hematuria, but the other 3 cases showed normal urinalysis. Light microscopy revealed minor glomerular abnormality in all the cases. Immunofluorescent study showed predominant mesangial C1q deposits with IgG, IgM and C3 in all cases. All selected specimens presented electron dense-depos in the mesangium. Ten years later from the detection, 2 cases continued to be normal urinalysis and 3 cases had mild proteinuria without hematuria. During this follow-up period, no cases presented with persistent proteinuria and/or hematuria greater than or equal to 2+ by dip stick test. And no cases developed systemic lupus erythematosus. Follow-up renal graft biopsies were performed once in 2 cases 8 years later from the detection. They showed minor glomerular abnormalities. C1q deposit disappeared in one case. In another case, immunofluorescent study was not examined. Conclusions This long-term observational study on transplanted kidneys confirms the existence of cases with predominant but silent C1q deposits in the mesangium who have negative or mild proteinuria.http://link.springer.com/article/10.1186/s12882-018-0874-9C1q nephropathyC1q depositsClinicopathologic studyProtocol renal graft biopsyRenal transplantation |
| spellingShingle | Takahiro Kanai Yuko Akioka Kenichiro Miura Masataka Hisano Junki Koike Yutaka Yamaguchi Motoshi Hattori Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study BMC Nephrology C1q nephropathy C1q deposits Clinicopathologic study Protocol renal graft biopsy Renal transplantation |
| title | Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study |
| title_full | Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study |
| title_fullStr | Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study |
| title_full_unstemmed | Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study |
| title_short | Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study |
| title_sort | predominant but silent c1q deposits in mesangium on transplanted kidneys long term observational study |
| topic | C1q nephropathy C1q deposits Clinicopathologic study Protocol renal graft biopsy Renal transplantation |
| url | http://link.springer.com/article/10.1186/s12882-018-0874-9 |
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