Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies
Objective: To systematically review the effects of caffeine on the development of cerebral palsy (CP). Design: Systematic review. Setting: A search of five databases was performed to identify randomized controlled trials (RCT) or cohort studies published through May 2022. Studies conducted on newbor...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229922001091 |
| _version_ | 1811173464259690496 |
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| author | Renata Cristina da Silva Ferreira Ana Carolina Felderheimer da Silva Michel Carlos Mocellin Cintia Chaves Curioni |
| author_facet | Renata Cristina da Silva Ferreira Ana Carolina Felderheimer da Silva Michel Carlos Mocellin Cintia Chaves Curioni |
| author_sort | Renata Cristina da Silva Ferreira |
| collection | DOAJ |
| description | Objective: To systematically review the effects of caffeine on the development of cerebral palsy (CP). Design: Systematic review. Setting: A search of five databases was performed to identify randomized controlled trials (RCT) or cohort studies published through May 2022. Studies conducted on newborns at risk of developing CP upon receiving caffeine in the first days of life were included as well. Two independent researchers assessed the screening, data extraction, and methodological quality assessment.Main outcome measures: Percentage of children with CP. Results: Four studies met our inclusion criteria. The only RCT found a decreased risk (approximately 40 %) of developing CP with 20 mg/kg caffeine citrate (OR 0.59, 95 % CI 0.39, 0.89). In addition, when comparing the period over which caffeine citrate was administered, one retrospective cohort study reported that infants who received caffeine up to the second day of life were also less likely to develop CP.Some methodological issues should be highlighted: in the RCT, the differences between the groups with respect to loss to follow-up were not explored. Similarly, intention-to-treat analyses were not performed. Most cohort studies have not adequately identified the primary confounding factors. Conclusions: Caffeine could be an important intervention in preventing CP. However, few studies have assessed the effects of caffeine on the risk of CP development. Due to methodological differences, no recommendation regarding its use can be safely made. The findings suggest a positive effect of caffeine citrate in the early stages of life with approximately 20 mg/kg of weight; however, well-designed RCTs with adequate sample size and power, randomization process, outcome measurement, and data analysis are still required. |
| first_indexed | 2024-04-10T17:47:22Z |
| format | Article |
| id | doaj.art-397ed0fa388c41479ec2ef74b8293cd9 |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-04-10T17:47:22Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-397ed0fa388c41479ec2ef74b8293cd92023-02-03T04:55:46ZengElsevierComplementary Therapies in Medicine0965-22992023-03-0172102906Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studiesRenata Cristina da Silva Ferreira0Ana Carolina Felderheimer da Silva1Michel Carlos Mocellin2Cintia Chaves Curioni3Nutrition Institute, University of State of Rio de Janeiro, R. São Francisco Xavier, 524 - 12º andar - Bloco D, Maracanã, Rio de Janeiro, RJ 20550-170, BrazilDepartment of Nutrition in Public Health, University of State of Rio de Janeiro, R. São Francisco Xavier, 524 - 12º andar - Bloco D - Maracanã, Rio de Janeiro, RJ 20550-170, BrazilDepartment of Fundamental Nutrition, Nutrition School, Federal University of the State of Rio de Janeiro, Avenida Pasteur, 296 - 3º andar - Urca, Rio de Janeiro, RJ 22290-240, BrazilDepartment of Nutrition in Public Health, University of State of Rio de Janeiro, R. São Francisco Xavier, 524 - 12º andar - Bloco D - Maracanã, Rio de Janeiro, RJ 20550-170, Brazil; Correspondence to: R. São Francisco Xavier, 524 - 12º andar - Bloco E – sala 12008 - Maracanã, Rio de Janeiro, RJ 20550-170, Brazil.Objective: To systematically review the effects of caffeine on the development of cerebral palsy (CP). Design: Systematic review. Setting: A search of five databases was performed to identify randomized controlled trials (RCT) or cohort studies published through May 2022. Studies conducted on newborns at risk of developing CP upon receiving caffeine in the first days of life were included as well. Two independent researchers assessed the screening, data extraction, and methodological quality assessment.Main outcome measures: Percentage of children with CP. Results: Four studies met our inclusion criteria. The only RCT found a decreased risk (approximately 40 %) of developing CP with 20 mg/kg caffeine citrate (OR 0.59, 95 % CI 0.39, 0.89). In addition, when comparing the period over which caffeine citrate was administered, one retrospective cohort study reported that infants who received caffeine up to the second day of life were also less likely to develop CP.Some methodological issues should be highlighted: in the RCT, the differences between the groups with respect to loss to follow-up were not explored. Similarly, intention-to-treat analyses were not performed. Most cohort studies have not adequately identified the primary confounding factors. Conclusions: Caffeine could be an important intervention in preventing CP. However, few studies have assessed the effects of caffeine on the risk of CP development. Due to methodological differences, no recommendation regarding its use can be safely made. The findings suggest a positive effect of caffeine citrate in the early stages of life with approximately 20 mg/kg of weight; however, well-designed RCTs with adequate sample size and power, randomization process, outcome measurement, and data analysis are still required.http://www.sciencedirect.com/science/article/pii/S0965229922001091Cerebral palsyCaffeineInfantsSystematic review |
| spellingShingle | Renata Cristina da Silva Ferreira Ana Carolina Felderheimer da Silva Michel Carlos Mocellin Cintia Chaves Curioni Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies Complementary Therapies in Medicine Cerebral palsy Caffeine Infants Systematic review |
| title | Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies |
| title_full | Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies |
| title_fullStr | Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies |
| title_full_unstemmed | Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies |
| title_short | Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies |
| title_sort | caffeine and cerebral palsy a systematic review of randomized controlled trials and cohort studies |
| topic | Cerebral palsy Caffeine Infants Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S0965229922001091 |
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