Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy
Herein, we present a one-pot hydrothermal approach for synthesizing metal–organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a P...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/3/822 |
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| author | Senthilkumar Thirumurugan Kayalvizhi Samuvel Muthiah Rajalakshmi Sakthivel Mei-Yi Liao Hitoshi Kasai Ren-Jei Chung |
| author_facet | Senthilkumar Thirumurugan Kayalvizhi Samuvel Muthiah Rajalakshmi Sakthivel Mei-Yi Liao Hitoshi Kasai Ren-Jei Chung |
| author_sort | Senthilkumar Thirumurugan |
| collection | DOAJ |
| description | Herein, we present a one-pot hydrothermal approach for synthesizing metal–organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.32% after PDA coating and exhibited good photothermal stability. Moreover, NWs with a suitable T<sub>1</sub> relaxivity coefficient (r<sub>1</sub> = 3.01 mg<sup>−1</sup> s<sup>−1</sup>) can be effectively used as magnetic resonance imaging (MRI) contrast agents. By increasing concentrations, cellular uptake studies showed a greater uptake of Cu-BTC@PDA NWs into cancer cells. Further, in vitro studies showed PDA-coated Cu-BTC NWs possess exceptional therapeutic performance by 808 nm laser irradiation, destroying 58% of cancer cells compared with the absence of laser irradiation. This promising performance is anticipated to advance the research and implementation of copper-based NWs as theranostic agents for cancer treatment. |
| first_indexed | 2024-03-11T06:01:59Z |
| format | Article |
| id | doaj.art-397f3c4078b5412c9a90df2feef71248 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:01:59Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-397f3c4078b5412c9a90df2feef712482023-11-17T13:14:51ZengMDPI AGPharmaceutics1999-49232023-03-0115382210.3390/pharmaceutics15030822Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal TherapySenthilkumar Thirumurugan0Kayalvizhi Samuvel Muthiah1Rajalakshmi Sakthivel2Mei-Yi Liao3Hitoshi Kasai4Ren-Jei Chung5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, TaiwanDepartment of Applied Chemistry, National Pingtung University, Pingtung 90003, TaiwanInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, JapanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, TaiwanHerein, we present a one-pot hydrothermal approach for synthesizing metal–organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.32% after PDA coating and exhibited good photothermal stability. Moreover, NWs with a suitable T<sub>1</sub> relaxivity coefficient (r<sub>1</sub> = 3.01 mg<sup>−1</sup> s<sup>−1</sup>) can be effectively used as magnetic resonance imaging (MRI) contrast agents. By increasing concentrations, cellular uptake studies showed a greater uptake of Cu-BTC@PDA NWs into cancer cells. Further, in vitro studies showed PDA-coated Cu-BTC NWs possess exceptional therapeutic performance by 808 nm laser irradiation, destroying 58% of cancer cells compared with the absence of laser irradiation. This promising performance is anticipated to advance the research and implementation of copper-based NWs as theranostic agents for cancer treatment.https://www.mdpi.com/1999-4923/15/3/822photothermal therapy (PTT)polydopamine (PDA)magnetic resonance imaging (MRI)nanowires (NWs) |
| spellingShingle | Senthilkumar Thirumurugan Kayalvizhi Samuvel Muthiah Rajalakshmi Sakthivel Mei-Yi Liao Hitoshi Kasai Ren-Jei Chung Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy Pharmaceutics photothermal therapy (PTT) polydopamine (PDA) magnetic resonance imaging (MRI) nanowires (NWs) |
| title | Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy |
| title_full | Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy |
| title_fullStr | Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy |
| title_full_unstemmed | Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy |
| title_short | Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy |
| title_sort | polydopamine coated cu btc nanowires for effective magnetic resonance imaging and photothermal therapy |
| topic | photothermal therapy (PTT) polydopamine (PDA) magnetic resonance imaging (MRI) nanowires (NWs) |
| url | https://www.mdpi.com/1999-4923/15/3/822 |
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