Senescent cells: New target for an old treatment?
Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the dru...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1299666 |
| _version_ | 1797677201605263360 |
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| author | Marco Demaria |
| author_facet | Marco Demaria |
| author_sort | Marco Demaria |
| collection | DOAJ |
| description | Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the drugs, providing a new target to reduce the toxicity of anticancer treatments. |
| first_indexed | 2024-03-11T22:41:38Z |
| format | Article |
| id | doaj.art-397f9ab42f534be19da9eaec64d61596 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:38Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-397f9ab42f534be19da9eaec64d615962023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-05-014310.1080/23723556.2017.12996661299666Senescent cells: New target for an old treatment?Marco Demaria0University Medical Center Groningen (UMCG), University of GroningenMany genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the drugs, providing a new target to reduce the toxicity of anticancer treatments.http://dx.doi.org/10.1080/23723556.2017.1299666cellular senescencechemotherapydrugsaspsenolytic |
| spellingShingle | Marco Demaria Senescent cells: New target for an old treatment? Molecular & Cellular Oncology cellular senescence chemotherapy drug sasp senolytic |
| title | Senescent cells: New target for an old treatment? |
| title_full | Senescent cells: New target for an old treatment? |
| title_fullStr | Senescent cells: New target for an old treatment? |
| title_full_unstemmed | Senescent cells: New target for an old treatment? |
| title_short | Senescent cells: New target for an old treatment? |
| title_sort | senescent cells new target for an old treatment |
| topic | cellular senescence chemotherapy drug sasp senolytic |
| url | http://dx.doi.org/10.1080/23723556.2017.1299666 |
| work_keys_str_mv | AT marcodemaria senescentcellsnewtargetforanoldtreatment |