Senescent cells: New target for an old treatment?

Senescent cells: New target for an old treatment?

Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the dru...

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Bibliographic Details
Main Author: Marco Demaria
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Molecular & Cellular Oncology
Subjects:
cellular senescence
chemotherapy
drug
sasp
senolytic
Online Access:http://dx.doi.org/10.1080/23723556.2017.1299666

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