SRC-2 Coactivator: a role in human metabolic evolution and disease
Abstract The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-05-01
|
| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10020-020-00168-0 |
| _version_ | 1818963390497816576 |
|---|---|
| author | Bert W. O’Malley |
| author_facet | Bert W. O’Malley |
| author_sort | Bert W. O’Malley |
| collection | DOAJ |
| description | Abstract The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective. |
| first_indexed | 2024-12-20T12:44:27Z |
| format | Article |
| id | doaj.art-39837489adad46b790a65321f47d04b1 |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-12-20T12:44:27Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-39837489adad46b790a65321f47d04b12022-12-21T19:40:22ZengBMCMolecular Medicine1076-15511528-36582020-05-012611410.1186/s10020-020-00168-0SRC-2 Coactivator: a role in human metabolic evolution and diseaseBert W. O’Malley0Department of Molecular and Cellular Biology, Baylor College of MedicineAbstract The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective.http://link.springer.com/article/10.1186/s10020-020-00168-0SRC-2CoactivatorsMetabolism |
| spellingShingle | Bert W. O’Malley SRC-2 Coactivator: a role in human metabolic evolution and disease Molecular Medicine SRC-2 Coactivators Metabolism |
| title | SRC-2 Coactivator: a role in human metabolic evolution and disease |
| title_full | SRC-2 Coactivator: a role in human metabolic evolution and disease |
| title_fullStr | SRC-2 Coactivator: a role in human metabolic evolution and disease |
| title_full_unstemmed | SRC-2 Coactivator: a role in human metabolic evolution and disease |
| title_short | SRC-2 Coactivator: a role in human metabolic evolution and disease |
| title_sort | src 2 coactivator a role in human metabolic evolution and disease |
| topic | SRC-2 Coactivators Metabolism |
| url | http://link.springer.com/article/10.1186/s10020-020-00168-0 |
| work_keys_str_mv | AT bertwomalley src2coactivatoraroleinhumanmetabolicevolutionanddisease |