Bistability of a coupled Aurora B kinase-phosphatase system in cell division

Bistability of a coupled Aurora B kinase-phosphatase system in cell division

Aurora B kinase, a key regulator of cell division, localizes to specific cellular locations, but the regulatory mechanisms responsible for phosphorylation of substrates located remotely from kinase enrichment sites are unclear. Here, we provide evidence that this activity at a distance depends on bo...

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Bibliographic Details
Main Authors: Anatoly V Zaytsev, Dario Segura-Peña, Maxim Godzi, Abram Calderon, Edward R Ballister, Rumen Stamatov, Alyssa M Mayo, Laura Peterson, Ben E Black, Fazly I Ataullakhanov, Michael A Lampson, Ekaterina L Grishchuk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
kinetochore
phosphorylation
enzyme kinetics
spatio-temporal dynamics
mathematical modeling
mitosis
Online Access:https://elifesciences.org/articles/10644

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