Recent Advances in the Modeling of Alzheimer’s Disease

Recent Advances in the Modeling of Alzheimer’s Disease

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) cDNA is overexpressed (1st generation models). Although many of these models successfully recapitulate major pathological h...

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Bibliographic Details
Main Authors: Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
amyloid – beta
amyloidosis
tau propagation
somatostatin
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.807473/full

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