The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs
Background: Zinc oxide Nanoparticles (NPs) present irreversible effects on the nervous system, memory, and learning. Objective: The current study aimed to investigate the effects of pentoxifylline on memory impairments, CA1 hippocampal pyramidal cells, and blood serum antioxidant enzymes in male...
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| Format: | Article |
| Language: | fas |
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Qazvin University of Medical Sciences & Health Services
2021-04-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.qums.ac.ir/article-1-3042-en.html |
| _version_ | 1818716333525696512 |
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| author | Niloufar Darbandi Zeynab Vasheghani Farahani Hamidreza Momeni |
| author_facet | Niloufar Darbandi Zeynab Vasheghani Farahani Hamidreza Momeni |
| author_sort | Niloufar Darbandi |
| collection | DOAJ |
| description | Background: Zinc oxide Nanoparticles (NPs) present irreversible effects on the nervous system,
memory, and learning.
Objective: The current study aimed to investigate the effects of pentoxifylline on memory
impairments, CA1 hippocampal pyramidal cells, and blood serum antioxidant enzymes in male
rats treated with zinc oxide NPs.
Methods: Male Wistar rats were divided into the control, zinc oxide NPs (1.25 mg/kg),
pentoxifylline (50 mg/kg), and pentoxifylline with zinc oxide NPs groups. In all study groups,
saline, zinc oxide NPs, and pentoxifylline were intraperitoneally injected 30 minutes before
training. In the co-treatment group, pentoxifylline was injected one hour before injecting Zno
NPs. After performing the behavioral test, the tested animals’ brains were fixed and the number
of healthy neurons in the CA1 region of the hippocampus was counted. In all research groups,
malondialdehyde levels, total antioxidant power, superoxide dismutase levels, and glutathione
peroxidase in blood serum were measured.
Results: Zinc oxide nanoparticles decreased memory and the number of healthy neurons in the
CA1 region of the hippocampus and increased oxidative stress in blood serum, compared to the
controls. In the co-treatment group, using pentoxifylline improved the above-mentioned factors
and reached the level of the control group. Pentoxifylline alone presented no significant effect on
the aforementioned characteristics, compared to the control group.
Conclusion: ZnO NPs may decrease memory retrieval and cause cell death in the pyramidal
neurons of the CA1 region of the hippocampus by increasing oxidative stress. Pentoxifylline, as
a potent antioxidant, can prevent the harmful effects of ZnO NPs |
| first_indexed | 2024-12-17T19:17:36Z |
| format | Article |
| id | doaj.art-398454d46b224c00832a3f424f6f0859 |
| institution | Directory Open Access Journal |
| issn | 1561-3666 2228-7213 |
| language | fas |
| last_indexed | 2024-12-17T19:17:36Z |
| publishDate | 2021-04-01 |
| publisher | Qazvin University of Medical Sciences & Health Services |
| record_format | Article |
| series | The Journal of Qazvin University of Medical Sciences |
| spelling | doaj.art-398454d46b224c00832a3f424f6f08592022-12-21T21:35:42ZfasQazvin University of Medical Sciences & Health ServicesThe Journal of Qazvin University of Medical Sciences1561-36662228-72132021-04-01251110http://dx.doi.org/10.32598/JQUMS.25.1.1The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPsNiloufar Darbandi0Zeynab Vasheghani Farahani1Hamidreza Momeni2Department of Biology, Faculty of Science, Arak University, Arak, IranDepartment of Biology, Faculty of Science, Arak University, Arak, IranDepartment of Biology, Faculty of Science, Arak University, Arak, IranBackground: Zinc oxide Nanoparticles (NPs) present irreversible effects on the nervous system, memory, and learning. Objective: The current study aimed to investigate the effects of pentoxifylline on memory impairments, CA1 hippocampal pyramidal cells, and blood serum antioxidant enzymes in male rats treated with zinc oxide NPs. Methods: Male Wistar rats were divided into the control, zinc oxide NPs (1.25 mg/kg), pentoxifylline (50 mg/kg), and pentoxifylline with zinc oxide NPs groups. In all study groups, saline, zinc oxide NPs, and pentoxifylline were intraperitoneally injected 30 minutes before training. In the co-treatment group, pentoxifylline was injected one hour before injecting Zno NPs. After performing the behavioral test, the tested animals’ brains were fixed and the number of healthy neurons in the CA1 region of the hippocampus was counted. In all research groups, malondialdehyde levels, total antioxidant power, superoxide dismutase levels, and glutathione peroxidase in blood serum were measured. Results: Zinc oxide nanoparticles decreased memory and the number of healthy neurons in the CA1 region of the hippocampus and increased oxidative stress in blood serum, compared to the controls. In the co-treatment group, using pentoxifylline improved the above-mentioned factors and reached the level of the control group. Pentoxifylline alone presented no significant effect on the aforementioned characteristics, compared to the control group. Conclusion: ZnO NPs may decrease memory retrieval and cause cell death in the pyramidal neurons of the CA1 region of the hippocampus by increasing oxidative stress. Pentoxifylline, as a potent antioxidant, can prevent the harmful effects of ZnO NPshttps://journal.qums.ac.ir/article-1-3042-en.htmlmemoryoxidative stressratpentoxifyllinezinc oxide nps |
| spellingShingle | Niloufar Darbandi Zeynab Vasheghani Farahani Hamidreza Momeni The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs The Journal of Qazvin University of Medical Sciences memory oxidative stress rat pentoxifylline zinc oxide nps |
| title | The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs |
| title_full | The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs |
| title_fullStr | The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs |
| title_full_unstemmed | The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs |
| title_short | The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs |
| title_sort | effects of pentoxifylline on memory in male rats treated with zinc oxide nps |
| topic | memory oxidative stress rat pentoxifylline zinc oxide nps |
| url | https://journal.qums.ac.ir/article-1-3042-en.html |
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